Chromatography methods in investigation of lipophilicity of the biological active substances

Abstract

This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role.

U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto.