Anabolic steroid and peptid hormones as doping agents in sports

Abstract

The use of hormones with anabolic action is present in competitive and amateur sports. World and Serbian anti-doping agencies forbid the use of anabolic hormones of steroid (testosterone and anabolic-androgenic steroids) and peptid structure (growth hormone, insulin-like growth factors, gonadotropins and insulin). In this article we review the pharmacologic actions, clinical uses and the characteristics of use and detection of these hormones as doping agents, with particular attention on side effects and health risks that might follow their misuse.

Primena hormona sa anaboličkim efektom veoma je zastupljena u takmičarskom i rekreativnom sportu. Svetska i nacionalna anti-doping agencija zabranjuju upotrebu anaboličkih hormona steroidne (testosterona i anaboličko-androgenih steroida) i peptidne strukture (hormona rasta, insulinu-sličnih faktora rasta, gonadotropina i insulina). U ovom radu dat je pregled farmakoloških dejstava, kliničke primene i karakteristika primene, kao i detekcije ovih hormona kao dopinga u sportu, sa posebnim akcentom na neželjene efekte i zdravstvene rizike koji se pri tom mogu javiti.