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dc.creatorLetica, Jelena
dc.creatorMarković, Slavko
dc.creatorZirojević, Jelena
dc.creatorNikolić, Katarina
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T11:20:09Z
dc.date.available2019-09-02T11:20:09Z
dc.date.issued2010
dc.identifier.issn1060-3271
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1334
dc.description.abstractAn RP-HPLC method for simultaneous separation and quantification of pantoprazole and its five main impurities in pharmaceutical formulations was developed and validated. The separation was accomplished on a Zorbax Eclipse XDB C18 column (5 mu m particle size, 150 x 4.6 mm id) using a gradient with mobile phase A [buffer-acetonitrile (70 + 30, v/v)], and mobile phase B [buffer-acetonitrile (30 + 70, v/v)]. The buffer was 0.01 M ammonium acetate solution with addition of 1 mL triethylamine/L of the solution, adjusted to pH 4.5 with orthophosphoric acid. The eluent flow rate was 1 mL/min, the temperature of the column was 30 C, and the eluate was monitored at 290 nm. Linearity (r = 0.999), recovery (97.6-105.8%), RSD (0.55-1.90%), and LOQ (0.099-1.48 mu g/mL) were evaluated and found to be satisfactory. The proposed method can be used for simultaneous identification and quantification of the analyzed compounds in pharmaceutical formulations.en
dc.publisherAOAC Int, Gaithersburg
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142071/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of AOAC International
dc.titleHigh-Performance Liquid Chromatographic Determination of Pantoprazole and Its Main Impurities in Pharmaceuticalsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAгбаба, Даница; Летица, Јелена; Марковић, Славко; Николић, Катарина; Зиројевић, Јелена;
dc.citation.volume93
dc.citation.issue4
dc.citation.spage1121
dc.citation.epage1128
dc.citation.other93(4): 1121-1128
dc.citation.rankM22
dc.identifier.wos000281492100009
dc.identifier.pmid20922942
dc.identifier.scopus2-s2.0-77956162993
dc.identifier.rcubconv_2345
dc.type.versionpublishedVersion


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