A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.
Keywords:
Gas chromatography-electron capture detection / Pharmaceutical products / Shampoo, gel and emulsion / Lindane
TY - JOUR
AU - Vujić, Zorica
AU - Matić, Silvana
AU - Kuntić, Vesna
AU - Vladimirov, Sote
AU - Uskoković-Marković, Snežana
PY - 2010
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1339
AB - A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.
PB - Springer Heidelberg, Heidelberg
T2 - Chromatographia
T1 - GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products
VL - 72
IS - 5-6
SP - 581
EP - 584
DO - 10.1365/s10337-010-1684-9
UR - conv_2340
ER -
@article{
author = "Vujić, Zorica and Matić, Silvana and Kuntić, Vesna and Vladimirov, Sote and Uskoković-Marković, Snežana",
year = "2010",
abstract = "A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products",
volume = "72",
number = "5-6",
pages = "581-584",
doi = "10.1365/s10337-010-1684-9",
url = "conv_2340"
}
Vujić, Z., Matić, S., Kuntić, V., Vladimirov, S.,& Uskoković-Marković, S.. (2010). GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products. in Chromatographia
Springer Heidelberg, Heidelberg., 72(5-6), 581-584.
https://doi.org/10.1365/s10337-010-1684-9
conv_2340
Vujić Z, Matić S, Kuntić V, Vladimirov S, Uskoković-Marković S. GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products. in Chromatographia. 2010;72(5-6):581-584.
doi:10.1365/s10337-010-1684-9
conv_2340 .
Vujić, Zorica, Matić, Silvana, Kuntić, Vesna, Vladimirov, Sote, Uskoković-Marković, Snežana, "GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products" in Chromatographia, 72, no. 5-6 (2010):581-584,
https://doi.org/10.1365/s10337-010-1684-9 .,
conv_2340 .
