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GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products

Authorized Users Only
2010
Authors
Vujić, Zorica
Matić, Silvana
Kuntić, Vesna
Vladimirov, Sote
Uskoković-Marković, Snežana
Article (Published version)
Metadata
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Abstract
A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.
Keywords:
Gas chromatography-electron capture detection / Pharmaceutical products / Shampoo, gel and emulsion / Lindane
Source:
Chromatographia, 2010, 72, 5-6, 581-584
Publisher:
  • Springer Heidelberg, Heidelberg
Funding / projects:
  • Supstance za farmaceutsku upotrebu: modeliranje, sinteza, fizičko-hemijske i biološke osobine, stepen čistoće i ispitivanje doziranih oblika (RS-142072)

DOI: 10.1365/s10337-010-1684-9

ISSN: 0009-5893

WoS: 000281174300029

Scopus: 2-s2.0-77957018484
[ Google Scholar ]
3
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1339
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Vujić, Zorica
AU  - Matić, Silvana
AU  - Kuntić, Vesna
AU  - Vladimirov, Sote
AU  - Uskoković-Marković, Snežana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1339
AB  - A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.
PB  - Springer Heidelberg, Heidelberg
T2  - Chromatographia
T1  - GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products
VL  - 72
IS  - 5-6
SP  - 581
EP  - 584
DO  - 10.1365/s10337-010-1684-9
ER  - 
@article{
author = "Vujić, Zorica and Matić, Silvana and Kuntić, Vesna and Vladimirov, Sote and Uskoković-Marković, Snežana",
year = "2010",
abstract = "A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products",
volume = "72",
number = "5-6",
pages = "581-584",
doi = "10.1365/s10337-010-1684-9"
}
Vujić, Z., Matić, S., Kuntić, V., Vladimirov, S.,& Uskoković-Marković, S.. (2010). GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products. in Chromatographia
Springer Heidelberg, Heidelberg., 72(5-6), 581-584.
https://doi.org/10.1365/s10337-010-1684-9
Vujić Z, Matić S, Kuntić V, Vladimirov S, Uskoković-Marković S. GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products. in Chromatographia. 2010;72(5-6):581-584.
doi:10.1365/s10337-010-1684-9 .
Vujić, Zorica, Matić, Silvana, Kuntić, Vesna, Vladimirov, Sote, Uskoković-Marković, Snežana, "GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products" in Chromatographia, 72, no. 5-6 (2010):581-584,
https://doi.org/10.1365/s10337-010-1684-9 . .

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