GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products
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A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.
Keywords:Gas chromatography-electron capture detection / Pharmaceutical products / Shampoo, gel and emulsion / Lindane
Source:Chromatographia, 2010, 72, 5-6, 581-584
- Springer Heidelberg, Heidelberg