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Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts

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Authors
Zdunić, Gordana
Gođevac, Dejan
Milenković, Marina
Šavikin, Katarina
Menković, Nebojša
Petrović, Silvana
Article (Published version)
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Abstract
Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent.
Keywords:
Hypericum richeri Vill. / oil extracts / quercetin / I3,II8-biapigenin / anti-inflammatory activity / gastroprotective activity
Source:
Natural Product Communications, 2010, 5, 8, 1215-1218
Publisher:
  • Natural Products Inc, Westerville
Projects:
  • Biljni proizvodi u preventivi i terapiji nezaraznih hroničnih oboljenja kod ljudi (RS-20035)

ISSN: 1934-578X

PubMed: 20839622

WoS: 000281074200014

Scopus: 2-s2.0-77956713475
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1343
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Pharmacy

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