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dc.creatorZdunić, Gordana
dc.creatorGođevac, Dejan
dc.creatorMilenković, Marina
dc.creatorŠavikin, Katarina
dc.creatorMenković, Nebojša
dc.creatorPetrović, Silvana
dc.date.accessioned2019-09-02T11:20:24Z
dc.date.available2019-09-02T11:20:24Z
dc.date.issued2010
dc.identifier.issn1934-578X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1343
dc.description.abstractOil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent.en
dc.publisherNatural Products Inc, Westerville
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/20035/RS//
dc.rightsrestrictedAccess
dc.sourceNatural Product Communications
dc.subjectHypericum richeri Vill.en
dc.subjectoil extractsen
dc.subjectquercetinen
dc.subjectI3,II8-biapigeninen
dc.subjectanti-inflammatory activityen
dc.subjectgastroprotective activityen
dc.titleAnti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extractsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГођевац, Дејан; Петровић, Силвана; Шавикин, Катарина; Миленковић, Марина; Менковић, Небојша; Здунић, Гордана;
dc.citation.volume5
dc.citation.issue8
dc.citation.spage1215
dc.citation.epage1218
dc.citation.other5(8): 1215-1218
dc.citation.rankM22
dc.identifier.wos000281074200014
dc.identifier.pmid20839622
dc.identifier.scopus2-s2.0-77956713475
dc.identifier.rcubconv_2338
dc.type.versionpublishedVersion


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