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Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples

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Authors
Aleksić, Mara
Kapetanović, Vera
Article (Published version)
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Abstract
In the last two decades different electroanalytical methods were used for sensitive and selective determination of cephalosporins. The paper was focused on the electrochemical behavior of methoxyimino cephalosporins, reduction mechanism and nature of the process at the mercury electrode surface. Special attention was paid to the cephalosporins adsorption at the mercury surface. Based on this phenomenon, the adsorptive stripping methods were established for determination of the low concentration of these drugs in urine samples, both in vitro, and in vivo conditions. The application of Adsorptive Stripping Differential Pulse Voltammetry (AdSDPV) for the determination of cefpodoxime proxetil (CP), cefotaxime (CF), desacetylcefotaxime (DCF) and cefetamet (CEF) was summarized. The best sensitivity of in vitro determination in urine was achieved for CP, in acid solutions (LOD 7.4.10(-9) M and LOQ 2.4.10(-8) M), followed by CF, CEF and DCF. This is in accordance with the strength of their ads...orption. Determination of CF and DCF by AdSDPV in vivo was also presented. Compared to other analytical methods, AdSDPV showed advantages in the simplicity of sample preparation, and over the other voltamperometric methods, higher sensitivity and selectivity.

Keywords:
Methoxyimino cephalosporins / reduction / adsorption / AdSDPV determination / urine
Source:
Combinatorial Chemistry & High Throughput Screening, 2010, 13, 8, 758-763
Publisher:
  • Bentham Science Publ Ltd, Sharjah
Funding / projects:
  • Sinteza, kvantitativni odnosi između strukture/osobina i aktivnosti, fizičko-hemijska karakterizacija i analiza farmakološki aktivnih supstanci (RS-142071)

ISSN: 1386-2073

PubMed: 20426735

WoS: 000280524800011

Scopus: 2-s2.0-77955736737
[ Google Scholar ]
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Handle
https://hdl.handle.net/21.15107/rcub_farfar_1345
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1345
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1345
AB  - In the last two decades different electroanalytical methods were used for sensitive and selective determination of cephalosporins. The paper was focused on the electrochemical behavior of methoxyimino cephalosporins, reduction mechanism and nature of the process at the mercury electrode surface. Special attention was paid to the cephalosporins adsorption at the mercury surface. Based on this phenomenon, the adsorptive stripping methods were established for determination of the low concentration of these drugs in urine samples, both in vitro, and in vivo conditions. The application of Adsorptive Stripping Differential Pulse Voltammetry (AdSDPV) for the determination of cefpodoxime proxetil (CP), cefotaxime (CF), desacetylcefotaxime (DCF) and cefetamet (CEF) was summarized. The best sensitivity of in vitro determination in urine was achieved for CP, in acid solutions (LOD 7.4.10(-9) M and LOQ 2.4.10(-8) M), followed by CF, CEF and DCF. This is in accordance with the strength of their adsorption. Determination of CF and DCF by AdSDPV in vivo was also presented. Compared to other analytical methods, AdSDPV showed advantages in the simplicity of sample preparation, and over the other voltamperometric methods, higher sensitivity and selectivity.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Combinatorial Chemistry & High Throughput Screening
T1  - Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples
VL  - 13
IS  - 8
SP  - 758
EP  - 763
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1345
ER  - 
@article{
author = "Aleksić, Mara and Kapetanović, Vera",
year = "2010",
abstract = "In the last two decades different electroanalytical methods were used for sensitive and selective determination of cephalosporins. The paper was focused on the electrochemical behavior of methoxyimino cephalosporins, reduction mechanism and nature of the process at the mercury electrode surface. Special attention was paid to the cephalosporins adsorption at the mercury surface. Based on this phenomenon, the adsorptive stripping methods were established for determination of the low concentration of these drugs in urine samples, both in vitro, and in vivo conditions. The application of Adsorptive Stripping Differential Pulse Voltammetry (AdSDPV) for the determination of cefpodoxime proxetil (CP), cefotaxime (CF), desacetylcefotaxime (DCF) and cefetamet (CEF) was summarized. The best sensitivity of in vitro determination in urine was achieved for CP, in acid solutions (LOD 7.4.10(-9) M and LOQ 2.4.10(-8) M), followed by CF, CEF and DCF. This is in accordance with the strength of their adsorption. Determination of CF and DCF by AdSDPV in vivo was also presented. Compared to other analytical methods, AdSDPV showed advantages in the simplicity of sample preparation, and over the other voltamperometric methods, higher sensitivity and selectivity.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Combinatorial Chemistry & High Throughput Screening",
title = "Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples",
volume = "13",
number = "8",
pages = "758-763",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1345"
}
Aleksić, M.,& Kapetanović, V.. (2010). Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples. in Combinatorial Chemistry & High Throughput Screening
Bentham Science Publ Ltd, Sharjah., 13(8), 758-763.
https://hdl.handle.net/21.15107/rcub_farfar_1345
Aleksić M, Kapetanović V. Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples. in Combinatorial Chemistry & High Throughput Screening. 2010;13(8):758-763.
https://hdl.handle.net/21.15107/rcub_farfar_1345 .
Aleksić, Mara, Kapetanović, Vera, "Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples" in Combinatorial Chemistry & High Throughput Screening, 13, no. 8 (2010):758-763,
https://hdl.handle.net/21.15107/rcub_farfar_1345 .

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