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dc.creatorAleksić, Mara
dc.creatorKapetanović, Vera
dc.date.accessioned2019-09-02T11:20:26Z
dc.date.available2019-09-02T11:20:26Z
dc.date.issued2010
dc.identifier.issn1386-2073
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1345
dc.description.abstractIn the last two decades different electroanalytical methods were used for sensitive and selective determination of cephalosporins. The paper was focused on the electrochemical behavior of methoxyimino cephalosporins, reduction mechanism and nature of the process at the mercury electrode surface. Special attention was paid to the cephalosporins adsorption at the mercury surface. Based on this phenomenon, the adsorptive stripping methods were established for determination of the low concentration of these drugs in urine samples, both in vitro, and in vivo conditions. The application of Adsorptive Stripping Differential Pulse Voltammetry (AdSDPV) for the determination of cefpodoxime proxetil (CP), cefotaxime (CF), desacetylcefotaxime (DCF) and cefetamet (CEF) was summarized. The best sensitivity of in vitro determination in urine was achieved for CP, in acid solutions (LOD 7.4.10(-9) M and LOQ 2.4.10(-8) M), followed by CF, CEF and DCF. This is in accordance with the strength of their adsorption. Determination of CF and DCF by AdSDPV in vivo was also presented. Compared to other analytical methods, AdSDPV showed advantages in the simplicity of sample preparation, and over the other voltamperometric methods, higher sensitivity and selectivity.en
dc.publisherBentham Science Publ Ltd, Sharjah
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142071/RS//
dc.rightsrestrictedAccess
dc.sourceCombinatorial Chemistry & High Throughput Screening
dc.subjectMethoxyimino cephalosporinsen
dc.subjectreductionen
dc.subjectadsorptionen
dc.subjectAdSDPV determinationen
dc.subjecturineen
dc.titleApplication of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samplesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКапетановић, Вера; Aлексић, Мара;
dc.citation.volume13
dc.citation.issue8
dc.citation.spage758
dc.citation.epage763
dc.citation.other13(8): 758-763
dc.citation.rankM21
dc.identifier.wos000280524800011
dc.identifier.pmid20426735
dc.identifier.scopus2-s2.0-77955736737
dc.identifier.rcubconv_2334
dc.type.versionpublishedVersion


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