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dc.creatorAleksić, Mara
dc.creatorRadulović, Valentina
dc.creatorKapetanović, Vera
dc.creatorSavić, Vladimir
dc.date.accessioned2019-09-02T11:20:47Z
dc.date.available2019-09-02T11:20:47Z
dc.date.issued2010
dc.identifier.issn1318-0207
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1359
dc.description.abstractThe electrochemical behaviour of desloratadine (DLOR) and its derivative 3-hydroxydesloratadine (3OH-DLOR) was investigated by direct current (DCP) polarography, cyclic (CV), differential pulse (DPV) and square-wave (SWV) voltammetry in Britton-Robinson (BR) buffer solutions (pH 4-11). Both compounds are reduced at mercury electrode in irreversible two electron reduction of the C=N bond of the pyridine ring in their molecules. The difference in their electrochemical behaviour was investigated, and the most pronounced distinction is observed at pH > 9, as a consequence of the deprotonation of the phenolic moiety in 3OH-DLOR molecule, yielding significant change in their reduction potentials (E (p DLOR) = -1.48 V, and E(p 3OH-DLOR) = -1.6 V). The observed results correlate with calculated LUMO energy levels and Hammet substituent constants (sigma). Based on the difference in the reduction potential for DLOR and 3OH-DLOR, conditions for simultaneous determination these two molecules in alkaline medium were established. The best selectivity was achieved using SWV method at pH 10. The linearity of the calibration graphs were achieved in the concentration range from 1.5 x 10(-6) M-1 x 10(-5) M for DLOR and 7.5 x 10(-6) M(-5) x 10(-5) M for 3OH-DLOR with detection limits of 2.29 x 10(-7) M and 2.08 x 10(-6) M, and determination limits of 7.64 x 10(-7) M and 6.94 x 10(-6) M, for DLOR and 3OH-DLOR, respectively. The method was checked in human plasma sample. Good response was obtained with LOD and LOQ values of 4.63 x 10(-7) M and 1.54 x 10(-6) M, for DLOR and 2.39 x 10(-6) M and 7.97 x 10(-6) M, 3OH-DLOR, respectively.en
dc.publisherSlovensko Kemijsko Drustvo, Ljubljana
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142071/RS//
dc.rightsopenAccess
dc.sourceActa Chimica Slovenica
dc.subjectDesloratadineen
dc.subject3-hydroxydesloratadineen
dc.subjectsimultaneous determinationen
dc.subjectvoltammetryen
dc.subjectbufferen
dc.subjectplasmaen
dc.titleThe Possibility of Simultaneous Voltammetric Determination of Desloratadine and 3-Hydroxydesloratadineen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractРадуловић, Валентина; Aлексић, Мара; Капетановић, Вера; Савић, Владимир;
dc.citation.volume57
dc.citation.issue3
dc.citation.spage686
dc.citation.epage692
dc.citation.other57(3): 686-692
dc.citation.rankM22
dc.identifier.wos000282093600025
dc.identifier.pmid24061817
dc.identifier.scopus2-s2.0-77957005147
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/273/1357.pdf
dc.identifier.rcubconv_2352
dc.type.versionpublishedVersion


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