Cationic surfactants-modified natural zeolites: improvement of the excipients functionality
Samo za registrovane korisnike
2010
Autori
Krajišnik, Danina
Milojević, Maja

Malenović, Anđelija

Daković, Aleksandra
Ibrić, Svetlana

Savić, Snežana

Dondur, Vera

Matijasević, Srdan
Radulović, Aleksandra
Daniels, Rolf
Milić, Jela
Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Context: In this study an investigation of cationic surfactants-modified natural zeolites as drug formulation excipient was performed. Objective: The aim of this work was to carry out a study of the purified natural zeolitic tuff with high amount of clinoptilolite as a potential carrier for molecules of pharmaceutical interest. Materials and methods: Two cationic surfactants (benzalkonium chloride and hexadecyltrimethylammonium bromide) were used for modification of the zeolitic surface in two levels (equal to and twice as external cation-exchange capacity of the zeolitic tuff). Prepared samples were characterized by Fourier transform infrared spectroscopy, thermogravimetric, high-performance liquid chromatography analysis, and powder flow determination. Different surfactant/zeolite composites were used for additional investigation of three model drugs: diclofenac diethylamine, diclofenac sodium, and ibuprofen by means of adsorption isotherm measurements in aqueous solutions. Results: ...The modified zeolites with two levels of surfactant coverage within the short activation time were prepared. Determination of flow properties showed that modification of zeolitic surface reflected on powder flow characteristics. Investigation of the model drugs adsorption on the obtained composites revealed that a variation between adsorption levels was influenced by the surfactant type and the amount present at the surface of the composites. Discussion and conclusion: In vitro release profiles of the drugs from the zeolite-surfactant-drug composites revealed that sustained drug release could be attained over a period of 8 hours. The presented results for drug uptake by surfactant-zeolite composites and the afterward drug release demonstrated the potential use of investigated modified natural zeolite as excipients for advanced excipients in drug formulations.
Ključne reči:
Adsorption / cationic surfactants / clinoptilolite / dissolution / drug carrier / excipients / mathematical model / physicochemical properties / zeolitic tuffIzvor:
Drug Development and Industrial Pharmacy, 2010, 36, 10, 1215-1224Izdavač:
- Informa Healthcare, London
Projekti:
DOI: 10.3109/03639041003695121
ISSN: 0363-9045
PubMed: 20367087