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Cationic surfactants-modified natural zeolites: improvement of the excipients functionality

Samo za registrovane korisnike
2010
Autori
Krajišnik, Danina
Milojević, Maja
Malenović, Anđelija
Daković, Aleksandra
Ibrić, Svetlana
Savić, Snežana
Dondur, Vera
Matijasević, Srdan
Radulović, Aleksandra
Daniels, Rolf
Milić, Jela
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
Context: In this study an investigation of cationic surfactants-modified natural zeolites as drug formulation excipient was performed. Objective: The aim of this work was to carry out a study of the purified natural zeolitic tuff with high amount of clinoptilolite as a potential carrier for molecules of pharmaceutical interest. Materials and methods: Two cationic surfactants (benzalkonium chloride and hexadecyltrimethylammonium bromide) were used for modification of the zeolitic surface in two levels (equal to and twice as external cation-exchange capacity of the zeolitic tuff). Prepared samples were characterized by Fourier transform infrared spectroscopy, thermogravimetric, high-performance liquid chromatography analysis, and powder flow determination. Different surfactant/zeolite composites were used for additional investigation of three model drugs: diclofenac diethylamine, diclofenac sodium, and ibuprofen by means of adsorption isotherm measurements in aqueous solutions. Results: ...The modified zeolites with two levels of surfactant coverage within the short activation time were prepared. Determination of flow properties showed that modification of zeolitic surface reflected on powder flow characteristics. Investigation of the model drugs adsorption on the obtained composites revealed that a variation between adsorption levels was influenced by the surfactant type and the amount present at the surface of the composites. Discussion and conclusion: In vitro release profiles of the drugs from the zeolite-surfactant-drug composites revealed that sustained drug release could be attained over a period of 8 hours. The presented results for drug uptake by surfactant-zeolite composites and the afterward drug release demonstrated the potential use of investigated modified natural zeolite as excipients for advanced excipients in drug formulations.

Ključne reči:
Adsorption / cationic surfactants / clinoptilolite / dissolution / drug carrier / excipients / mathematical model / physicochemical properties / zeolitic tuff
Izvor:
Drug Development and Industrial Pharmacy, 2010, 36, 10, 1215-1224
Izdavač:
  • Informa Healthcare, London
Projekti:
  • Razvoj i karakterizacija koloidnih nosača za antiinflamatorne lekove (RS-19058)

DOI: 10.3109/03639041003695121

ISSN: 0363-9045

PubMed: 20367087

WoS: 000282523500009

Scopus: 2-s2.0-77956407356
[ Google Scholar ]
24
19
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1364
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija
Pharmacy

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