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dc.creatorKrajišnik, Danina
dc.creatorMilojević, Maja
dc.creatorMalenović, Anđelija
dc.creatorDaković, Aleksandra
dc.creatorIbrić, Svetlana
dc.creatorSavić, Snežana
dc.creatorDondur, Vera
dc.creatorMatijasević, Srdan
dc.creatorRadulović, Aleksandra
dc.creatorDaniels, Rolf
dc.creatorMilić, Jela
dc.date.accessioned2019-09-02T11:20:55Z
dc.date.available2019-09-02T11:20:55Z
dc.date.issued2010
dc.identifier.issn0363-9045
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1364
dc.description.abstractContext: In this study an investigation of cationic surfactants-modified natural zeolites as drug formulation excipient was performed. Objective: The aim of this work was to carry out a study of the purified natural zeolitic tuff with high amount of clinoptilolite as a potential carrier for molecules of pharmaceutical interest. Materials and methods: Two cationic surfactants (benzalkonium chloride and hexadecyltrimethylammonium bromide) were used for modification of the zeolitic surface in two levels (equal to and twice as external cation-exchange capacity of the zeolitic tuff). Prepared samples were characterized by Fourier transform infrared spectroscopy, thermogravimetric, high-performance liquid chromatography analysis, and powder flow determination. Different surfactant/zeolite composites were used for additional investigation of three model drugs: diclofenac diethylamine, diclofenac sodium, and ibuprofen by means of adsorption isotherm measurements in aqueous solutions. Results: The modified zeolites with two levels of surfactant coverage within the short activation time were prepared. Determination of flow properties showed that modification of zeolitic surface reflected on powder flow characteristics. Investigation of the model drugs adsorption on the obtained composites revealed that a variation between adsorption levels was influenced by the surfactant type and the amount present at the surface of the composites. Discussion and conclusion: In vitro release profiles of the drugs from the zeolite-surfactant-drug composites revealed that sustained drug release could be attained over a period of 8 hours. The presented results for drug uptake by surfactant-zeolite composites and the afterward drug release demonstrated the potential use of investigated modified natural zeolite as excipients for advanced excipients in drug formulations.en
dc.publisherInforma Healthcare, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/19058/RS//
dc.rightsrestrictedAccess
dc.sourceDrug Development and Industrial Pharmacy
dc.subjectAdsorptionen
dc.subjectcationic surfactantsen
dc.subjectclinoptiloliteen
dc.subjectdissolutionen
dc.subjectdrug carrieren
dc.subjectexcipientsen
dc.subjectmathematical modelen
dc.subjectphysicochemical propertiesen
dc.subjectzeolitic tuffen
dc.titleCationic surfactants-modified natural zeolites: improvement of the excipients functionalityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМатијасевић, Срдан; Ибрић, Светлана; Радуловић, Aлександра; Крајишник, Данина; Дондур, Вера; Маленовић, Aнђелија; Даковић, Aлександра; Милић, Јела; Даниелс, Ролф; Милојевић, Маја; Савић, Снежана;
dc.citation.volume36
dc.citation.issue10
dc.citation.spage1215
dc.citation.epage1224
dc.citation.other36(10): 1215-1224
dc.citation.rankM23
dc.identifier.wos000282523500009
dc.identifier.doi10.3109/03639041003695121
dc.identifier.pmid20367087
dc.identifier.scopus2-s2.0-77956407356
dc.identifier.rcubconv_2357
dc.type.versionpublishedVersion


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