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dc.creatorRudić, Jelena S.
dc.creatorĆulafić, Đorđe
dc.creatorMirković, Duško
dc.creatorJesić, Rada S.
dc.creatorKrstić, Miodrag N.
dc.date.accessioned2019-09-02T11:20:56Z
dc.date.available2019-09-02T11:20:56Z
dc.date.issued2010
dc.identifier.issn1007-9327
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1365
dc.description.abstractAIM: To determine the effect of free serotonin concentrations in plasma on development of esophageal and gastric fundal varices. METHODS: This prospective study included 33 patients with liver cirrhosis and 24 healthy controls. Ultrasonography and measurement of serotonin concentration in plasma were carried out in both groups of subjects. The upper fiber panendoscopy was performed only in patients with liver cirrhosis. RESULTS: The mean plasma free serotonin levels were much higher in liver cirrhosis patients than in healthy controls (219.0 +/- 24.2 nmol/L vs 65.4 +/- 18.7 nmol/L, P lt 0.0001). There was no significant correlation be-tween serotonin concentration in plasma and the size of the esophageal varices according to Spearman coefficient of correlation (r(s) = -0.217, P > 0.05). However, the correlation of plasma serotonin concentration and gastric fundal varices was highly significant (r(s) = -0.601, P lt 0.01). CONCLUSION: Free serotonin is significant in pathogenesis of portal hypertension especially in development of fundal varices, indicating the clinical value of serotonergic receptor blockers in these patients.en
dc.publisherBaishideng Publ Grp Co Ltd, Beijing
dc.relationMinistry of Science and Technological Development, Republic of Serbia - 14501B
dc.rightsopenAccess
dc.sourceWorld Journal of Microbiology & Biotechnology
dc.subjectSerotoninen
dc.subjectPortal hypertensionen
dc.subjectEsophageal varicesen
dc.subjectFundal varicesen
dc.subjectPlateletsen
dc.titleRole of serotonin in development of esophageal and gastric fundal varicesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈесић, Рада С.; Крстић, Миодраг Н.; Мирковић, Душко; Рудић, Јелена С.; Ћулафић, Ђорђе;
dc.citation.volume16
dc.citation.issue48
dc.citation.spage6135
dc.citation.epage6138
dc.citation.other16(48): 6135-6138
dc.citation.rankM22
dc.identifier.wos000285733600014
dc.identifier.doi10.3748/wjg.v16.i48.6135
dc.identifier.pmid21182230
dc.identifier.scopus2-s2.0-78650779472
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/278/1363.pdf
dc.identifier.rcubconv_2378
dc.type.versionpublishedVersion


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