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HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients

Authorized Users Only
2010
Authors
Stefanović, Aleksandra
Kotur-Stevuljević, Jelena
Spasić, Slavica
Vekić, Jelena
Zeljković, Aleksandra
Spasojević-Kalimanovska, Vesna
Jelić-Ivanović, Zorana
Article (Published version)
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Abstract
Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly ...HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.

Keywords:
Diabetes mellitus type 2 / Oxidative stress / Paraoxonase / HDL 2 particles
Source:
Clinical Biochemistry, 2010, 43, 15, 1230-1235
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.clinbiochem.2010.08.005

ISSN: 0009-9120

PubMed: 20709049

WoS: 000282204400010

Scopus: 2-s2.0-77956719446
[ Google Scholar ]
23
20
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1367
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1367
AB  - Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients
VL  - 43
IS  - 15
SP  - 1230
EP  - 1235
DO  - 10.1016/j.clinbiochem.2010.08.005
ER  - 
@article{
author = "Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasić, Slavica and Vekić, Jelena and Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana",
year = "2010",
abstract = "Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients",
volume = "43",
number = "15",
pages = "1230-1235",
doi = "10.1016/j.clinbiochem.2010.08.005"
}
Stefanović, A., Kotur-Stevuljević, J., Spasić, S., Vekić, J., Zeljković, A., Spasojević-Kalimanovska, V.,& Jelić-Ivanović, Z.. (2010). HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 43(15), 1230-1235.
https://doi.org/10.1016/j.clinbiochem.2010.08.005
Stefanović A, Kotur-Stevuljević J, Spasić S, Vekić J, Zeljković A, Spasojević-Kalimanovska V, Jelić-Ivanović Z. HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients. in Clinical Biochemistry. 2010;43(15):1230-1235.
doi:10.1016/j.clinbiochem.2010.08.005 .
Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Spasić, Slavica, Vekić, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, "HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients" in Clinical Biochemistry, 43, no. 15 (2010):1230-1235,
https://doi.org/10.1016/j.clinbiochem.2010.08.005 . .

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