HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients
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Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly ...HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.
Ključne reči:Diabetes mellitus type 2 / Oxidative stress / Paraoxonase / HDL 2 particles
Izvor:Clinical Biochemistry, 2010, 43, 15, 1230-1235
- Pergamon-Elsevier Science Ltd, Oxford