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dc.creatorStefanović, Aleksandra
dc.creatorKotur-Stevuljević, Jelena
dc.creatorSpasić, Slavica
dc.creatorVekić, Jelena
dc.creatorZeljković, Aleksandra
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:20:58Z
dc.date.available2019-09-02T11:20:58Z
dc.date.issued2010
dc.identifier.issn0009-9120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1367
dc.description.abstractObjectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectDiabetes mellitus type 2en
dc.subjectOxidative stressen
dc.subjectParaoxonaseen
dc.subjectHDL 2 particlesen
dc.titleHDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВекић, Јелена; Котур-Стевуљевић, Јелена; Јелић-Ивановић, Зорана; Стефановић, Aлександра; Спасић, Славица; Спасојевић-Калимановска, Весна; Зељковић, Aлександра;
dc.citation.volume43
dc.citation.issue15
dc.citation.spage1230
dc.citation.epage1235
dc.citation.other43(15): 1230-1235
dc.citation.rankM22
dc.identifier.wos000282204400010
dc.identifier.doi10.1016/j.clinbiochem.2010.08.005
dc.identifier.pmid20709049
dc.identifier.scopus2-s2.0-77956719446
dc.identifier.rcubconv_2354
dc.type.versionpublishedVersion


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