Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis
Authorized Users Only
2010
Authors
Martinović, JelenaKotur-Stevuljević, Jelena
Dopsaj, Violeta
Dopsaj, Milivoj
Stefanović, Aleksandra
Kasum, Goran
Article (Published version)
Metadata
Show full item recordAbstract
Objective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stage...s of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity.
Keywords:
Paraoxonase / Iron deficiency / Ferritin / Deficient erythropoiesis / Oxidative stress / Lipid hydroperoxides / Pro-oxidant-antioxidant balance / Exercise / Haemoglobin / Free radicalsSource:
Clinical Biochemistry, 2010, 43, 15, 1225-1229Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-MESTD-MPN2006-2010-145036)
DOI: 10.1016/j.clinbiochem.2010.07.024
ISSN: 0009-9120
PubMed: 20692246
WoS: 000282204400009
Scopus: 2-s2.0-77956746774
Collections
Institution/Community
PharmacyTY - JOUR AU - Martinović, Jelena AU - Kotur-Stevuljević, Jelena AU - Dopsaj, Violeta AU - Dopsaj, Milivoj AU - Stefanović, Aleksandra AU - Kasum, Goran PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1368 AB - Objective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stages of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis VL - 43 IS - 15 SP - 1225 EP - 1229 DO - 10.1016/j.clinbiochem.2010.07.024 ER -
@article{ author = "Martinović, Jelena and Kotur-Stevuljević, Jelena and Dopsaj, Violeta and Dopsaj, Milivoj and Stefanović, Aleksandra and Kasum, Goran", year = "2010", abstract = "Objective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stages of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis", volume = "43", number = "15", pages = "1225-1229", doi = "10.1016/j.clinbiochem.2010.07.024" }
Martinović, J., Kotur-Stevuljević, J., Dopsaj, V., Dopsaj, M., Stefanović, A.,& Kasum, G.. (2010). Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 43(15), 1225-1229. https://doi.org/10.1016/j.clinbiochem.2010.07.024
Martinović J, Kotur-Stevuljević J, Dopsaj V, Dopsaj M, Stefanović A, Kasum G. Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis. in Clinical Biochemistry. 2010;43(15):1225-1229. doi:10.1016/j.clinbiochem.2010.07.024 .
Martinović, Jelena, Kotur-Stevuljević, Jelena, Dopsaj, Violeta, Dopsaj, Milivoj, Stefanović, Aleksandra, Kasum, Goran, "Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis" in Clinical Biochemistry, 43, no. 15 (2010):1225-1229, https://doi.org/10.1016/j.clinbiochem.2010.07.024 . .