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Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis

Samo za registrovane korisnike
2010
Autori
Martinović, Jelena
Kotur-Stevuljević, Jelena
Dopsaj, Violeta
Dopsaj, Milivoj
Stefanović, Aleksandra
Kasum, Goran
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
Objective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stage...s of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity.

Ključne reči:
Paraoxonase / Iron deficiency / Ferritin / Deficient erythropoiesis / Oxidative stress / Lipid hydroperoxides / Pro-oxidant-antioxidant balance / Exercise / Haemoglobin / Free radicals
Izvor:
Clinical Biochemistry, 2010, 43, 15, 1225-1229
Izdavač:
  • Pergamon-Elsevier Science Ltd, Oxford
Projekti:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.clinbiochem.2010.07.024

ISSN: 0009-9120

PubMed: 20692246

WoS: 000282204400009

Scopus: 2-s2.0-77956746774
[ Google Scholar ]
7
3
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1368
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija
Pharmacy

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