Приказ основних података о документу
Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis
dc.creator | Martinović, Jelena | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Dopsaj, Violeta | |
dc.creator | Dopsaj, Milivoj | |
dc.creator | Stefanović, Aleksandra | |
dc.creator | Kasum, Goran | |
dc.date.accessioned | 2019-09-02T11:21:02Z | |
dc.date.available | 2019-09-02T11:21:02Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1368 | |
dc.description.abstract | Objective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stages of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | Paraoxonase | en |
dc.subject | Iron deficiency | en |
dc.subject | Ferritin | en |
dc.subject | Deficient erythropoiesis | en |
dc.subject | Oxidative stress | en |
dc.subject | Lipid hydroperoxides | en |
dc.subject | Pro-oxidant-antioxidant balance | en |
dc.subject | Exercise | en |
dc.subject | Haemoglobin | en |
dc.subject | Free radicals | en |
dc.title | Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Допсај, Виолета; Допсај, Миливој; Мартиновић, Јелена; Касум, Горан; Котур-Стевуљевић, Јелена; Стефановић, Aлександра; | |
dc.citation.volume | 43 | |
dc.citation.issue | 15 | |
dc.citation.spage | 1225 | |
dc.citation.epage | 1229 | |
dc.citation.other | 43(15): 1225-1229 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000282204400009 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2010.07.024 | |
dc.identifier.pmid | 20692246 | |
dc.identifier.scopus | 2-s2.0-77956746774 | |
dc.type.version | publishedVersion |