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dc.creatorMartinović, Jelena
dc.creatorKotur-Stevuljević, Jelena
dc.creatorDopsaj, Violeta
dc.creatorDopsaj, Milivoj
dc.creatorStefanović, Aleksandra
dc.creatorKasum, Goran
dc.date.accessioned2019-09-02T11:21:02Z
dc.date.available2019-09-02T11:21:02Z
dc.date.issued2010
dc.identifier.issn0009-9120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1368
dc.description.abstractObjective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stages of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectParaoxonaseen
dc.subjectIron deficiencyen
dc.subjectFerritinen
dc.subjectDeficient erythropoiesisen
dc.subjectOxidative stressen
dc.subjectLipid hydroperoxidesen
dc.subjectPro-oxidant-antioxidant balanceen
dc.subjectExerciseen
dc.subjectHaemoglobinen
dc.subjectFree radicalsen
dc.titleParaoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДопсај, Виолета; Допсај, Миливој; Мартиновић, Јелена; Касум, Горан; Котур-Стевуљевић, Јелена; Стефановић, Aлександра;
dc.citation.volume43
dc.citation.issue15
dc.citation.spage1225
dc.citation.epage1229
dc.citation.other43(15): 1225-1229
dc.citation.rankM22
dc.identifier.wos000282204400009
dc.identifier.doi10.1016/j.clinbiochem.2010.07.024
dc.identifier.pmid20692246
dc.identifier.scopus2-s2.0-77956746774
dc.identifier.rcubconv_2353
dc.type.versionpublishedVersion


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