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Premature Centromere Division of Metaphase Chromosomes in Peripheral Blood Lymphocytes of Alzheimer's Disease Patients: Relation to Gender and Age
dc.creator | Živković, Lada | |
dc.creator | Potparević, Biljana | |
dc.creator | Plećaš-Solarović, Bosiljka | |
dc.creator | Đelić, Ninoslav | |
dc.creator | Ocić, Gordana | |
dc.creator | Smiljković, Predrag | |
dc.creator | Siedlak, Sandra L. | |
dc.creator | Smith, Mark A. | |
dc.creator | Bajić, Vladan | |
dc.date.accessioned | 2019-09-02T11:21:03Z | |
dc.date.available | 2019-09-02T11:21:03Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1079-5006 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1370 | |
dc.description.abstract | Chromosomal alterations are a feature of both aging and Alzheimer's disease (AD). This study examined if premature centromere division (PCD), a chromosomal instability indicator increased in AD, is correlated with aging or, instead, represents a de novo chromosomal alteration due to accelerating aging in AD. PCD in peripheral blood lymphocytes was determined in sporadic AD patients and gender and age-matched unaffected controls. Metaphase nuclei were analyzed for chromosomes showing PCD, X chromosomes with PCD (PCD,X), and acrocentric chromosomes showing PCD. AD patients, regardless of age, demonstrated increased PCD on any chromosome and PCD on acrocentric chromosomes in both genders, whereas an increase in frequency of PCD,X was expressed only in women. This cytogenetic analysis suggests that PCD is a feature of AD, rather than an epiphenomenon of chronological aging, and may be useful as a physiological biomarker that can be used for disease diagnosis. | en |
dc.publisher | Oxford Univ Press Inc, Cary | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143018/RS// | |
dc.rights | openAccess | |
dc.source | Journals of Gerontology Series A: Biological Sciences and Medical Sciences | |
dc.subject | Age | en |
dc.subject | Chromosome | en |
dc.subject | Premature centromere division | en |
dc.subject | Sporadic Alzheimer's disease | en |
dc.title | Premature Centromere Division of Metaphase Chromosomes in Peripheral Blood Lymphocytes of Alzheimer's Disease Patients: Relation to Gender and Age | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Бајић, Владан; Живковић, Лада; Потпаревић, Биљана; Смиљковић, Предраг; Смитх, Марк A.; Ђелић, Нинослав; Плећаш-Соларовић, Босиљка; Оцић, Гордана; Сиедлак, Сандра Л.; | |
dc.citation.volume | 65 | |
dc.citation.issue | 12 | |
dc.citation.spage | 1269 | |
dc.citation.epage | 1274 | |
dc.citation.other | 65(12): 1269-1274 | |
dc.citation.rank | aM21 | |
dc.identifier.wos | 000284639700001 | |
dc.identifier.doi | 10.1093/gerona/glq148 | |
dc.identifier.pmid | 20805239 | |
dc.identifier.scopus | 2-s2.0-78649611512 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/283/1368.pdf | |
dc.type.version | publishedVersion |