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dc.creatorŽivković, Lada
dc.creatorPotparević, Biljana
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorĐelić, Ninoslav
dc.creatorOcić, Gordana
dc.creatorSmiljković, Predrag
dc.creatorSiedlak, Sandra L.
dc.creatorSmith, Mark A.
dc.creatorBajić, Vladan
dc.date.accessioned2019-09-02T11:21:03Z
dc.date.available2019-09-02T11:21:03Z
dc.date.issued2010
dc.identifier.issn1079-5006
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1370
dc.description.abstractChromosomal alterations are a feature of both aging and Alzheimer's disease (AD). This study examined if premature centromere division (PCD), a chromosomal instability indicator increased in AD, is correlated with aging or, instead, represents a de novo chromosomal alteration due to accelerating aging in AD. PCD in peripheral blood lymphocytes was determined in sporadic AD patients and gender and age-matched unaffected controls. Metaphase nuclei were analyzed for chromosomes showing PCD, X chromosomes with PCD (PCD,X), and acrocentric chromosomes showing PCD. AD patients, regardless of age, demonstrated increased PCD on any chromosome and PCD on acrocentric chromosomes in both genders, whereas an increase in frequency of PCD,X was expressed only in women. This cytogenetic analysis suggests that PCD is a feature of AD, rather than an epiphenomenon of chronological aging, and may be useful as a physiological biomarker that can be used for disease diagnosis.en
dc.publisherOxford Univ Press Inc, Cary
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143018/RS//
dc.rightsopenAccess
dc.sourceJournals of Gerontology Series A: Biological Sciences and Medical Sciences
dc.subjectAgeen
dc.subjectChromosomeen
dc.subjectPremature centromere divisionen
dc.subjectSporadic Alzheimer's diseaseen
dc.titlePremature Centromere Division of Metaphase Chromosomes in Peripheral Blood Lymphocytes of Alzheimer's Disease Patients: Relation to Gender and Ageen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБајић, Владан; Живковић, Лада; Потпаревић, Биљана; Смиљковић, Предраг; Смитх, Марк A.; Ђелић, Нинослав; Плећаш-Соларовић, Босиљка; Оцић, Гордана; Сиедлак, Сандра Л.;
dc.citation.volume65
dc.citation.issue12
dc.citation.spage1269
dc.citation.epage1274
dc.citation.other65(12): 1269-1274
dc.citation.rankaM21
dc.identifier.wos000284639700001
dc.identifier.doi10.1093/gerona/glq148
dc.identifier.pmid20805239
dc.identifier.scopus2-s2.0-78649611512
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/283/1368.pdf
dc.identifier.rcubconv_2371
dc.type.versionpublishedVersion


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