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dc.creatorJančić-Stojanović, Biljana
dc.creatorMalenović, Anđelija
dc.creatorMarković, Slavko
dc.creatorIvanović, Darko
dc.creatorMedenica, Mirjana
dc.date.accessioned2019-09-02T11:21:05Z
dc.date.available2019-09-02T11:21:05Z
dc.date.issued2010
dc.identifier.issn1060-3271
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1371
dc.description.abstractAn RP-HPLC method has been optimized and validated for the simultaneous determination of hydrocortisone acetate and of lidocaine in suppositories. For the method optimization, response surface methodology was applied, and the obtained model was tested using analysis of variance. The optimal separations were conducted on a Beckman-Coulter 150 x 4.6 mm, 5 pm particle-size column at 20 degrees C. The mobile phase was methanol-water (65 + 35, v/v), pH adjusted to 2.5 with 85% orthophosphoric acid, with a flow rate of 1.0 mL/min. UV detection was performed at 250 nm. Phenobarbital was used as an internal standard. The method was validated for selectivity, linearity, precision, and robustness.en
dc.publisherAOAC Int, Gaithersburg
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142077/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of AOAC International
dc.titleOptimization and Validation of an RP-HPLC Method for Analysis of Hydrocortisone Acetate and Lidocaine in Suppositoriesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈанчић-Стојановић, Биљана; Меденица, Мирјана; Ивановић, Дарко; Марковић, Славко; Маленовић, Aнђелија;
dc.citation.volume93
dc.citation.issue1
dc.citation.spage102
dc.citation.epage107
dc.citation.other93(1): 102-107
dc.citation.rankM22
dc.identifier.wos000275096600015
dc.identifier.pmid20334171
dc.identifier.scopus2-s2.0-77949987112
dc.identifier.rcubconv_2282
dc.type.versionpublishedVersion


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