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Optimization and Validation of an RP-HPLC Method for Analysis of Hydrocortisone Acetate and Lidocaine in Suppositories
dc.creator | Jančić-Stojanović, Biljana | |
dc.creator | Malenović, Anđelija | |
dc.creator | Marković, Slavko | |
dc.creator | Ivanović, Darko | |
dc.creator | Medenica, Mirjana | |
dc.date.accessioned | 2019-09-02T11:21:05Z | |
dc.date.available | 2019-09-02T11:21:05Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1060-3271 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1371 | |
dc.description.abstract | An RP-HPLC method has been optimized and validated for the simultaneous determination of hydrocortisone acetate and of lidocaine in suppositories. For the method optimization, response surface methodology was applied, and the obtained model was tested using analysis of variance. The optimal separations were conducted on a Beckman-Coulter 150 x 4.6 mm, 5 pm particle-size column at 20 degrees C. The mobile phase was methanol-water (65 + 35, v/v), pH adjusted to 2.5 with 85% orthophosphoric acid, with a flow rate of 1.0 mL/min. UV detection was performed at 250 nm. Phenobarbital was used as an internal standard. The method was validated for selectivity, linearity, precision, and robustness. | en |
dc.publisher | AOAC Int, Gaithersburg | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142077/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of AOAC International | |
dc.title | Optimization and Validation of an RP-HPLC Method for Analysis of Hydrocortisone Acetate and Lidocaine in Suppositories | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јанчић-Стојановић, Биљана; Меденица, Мирјана; Ивановић, Дарко; Марковић, Славко; Маленовић, Aнђелија; | |
dc.citation.volume | 93 | |
dc.citation.issue | 1 | |
dc.citation.spage | 102 | |
dc.citation.epage | 107 | |
dc.citation.other | 93(1): 102-107 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000275096600015 | |
dc.identifier.doi | 10.1093/jaoac/93.1.102 | |
dc.identifier.pmid | 20334171 | |
dc.identifier.scopus | 2-s2.0-77949987112 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1371 | |
dc.type.version | publishedVersion |