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dc.creatorVujović, Ana
dc.creatorKotur-Stevuljević, Jelena
dc.creatorSpasić, Slavica
dc.creatorBujisić, Nada
dc.creatorMartinović, Jelena
dc.creatorVujović, Milica
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorZeljković, Aleksandra
dc.creatorPajić, Dragoljub
dc.date.accessioned2019-09-02T11:21:10Z
dc.date.available2019-09-02T11:21:10Z
dc.date.issued2010
dc.identifier.issn1476-511X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1374
dc.description.abstractBackground: Friedewald's formula for the estimation of LDL-C concentration is the most often used formula in clinical practice. A recent formula by Anandaraja and colleagues for LDL-C estimation still needs to be evaluated before it is extensively applied in diagnosis. In the present study we validated existing formulas and derived a more accurate formula to determine LDL-C in a Serbian population. Methods: Our study included 2053 patients with TG lt = 4.52 mmol/L. In an initial group of 1010 patients, Friedewald's and Anandaraja's formulas were compared to a direct homogenous method for LDL-C determination. The obtained results allowed us to modify Friedewald's formula and apply it in a second group of patients. Results: The mean LDL-C concentrations were 3.9 +/- 1.09 mmol/L, 3.63 +/- 1.06 mmol/L and 3.72 +/- 1.04 mmol/L measured by a direct homogenous assay (D-LDL-C), calculated by Friedewald's formula (F-LDL-C) and calculated by Anandaraja's formula (A-LDL-C), respectively in the 1010 patients. The Student's paired t-test showed that D-LDL-C values were significantly higher than F-LDL-C and A-LDL-C values (p lt 0.001). The Passing-Bablok regression analysis indicated good correlation between calculated and measured LDL-Cs (r > 0.89). Using lipoprotein values from the initial group we modified Friedewald's formula by replacing the term 2.2 with 3. The new modified formula for LDL-C estimation (S-LDL-C) showed no statistically significant difference compared to D-LDL-C. The absolute bias between these two methods was -0.06 +/- 0.37 mmol/L with a high correlation coefficient (r = 0.96). Conclusions: Our modified formula for LDL-C estimation appears to be more accurate than both Friedewald's and Anandaraja's formulas when applied to a Serbian population.en
dc.publisherBMC, LONDON
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsopenAccess
dc.sourceLipids in Health and Disease
dc.titleEvaluation of different formulas for LDL-C calculationen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractБујисић, Нада; Зељковић, Aлександра; Пајић, Драгољуб; Вујовић, Милица; Котур-Стевуљевић, Јелена; Спасић, Славица; Спасојевић-Калимановска, Весна; Вујовић, Aна; Мартиновић, Јелена;
dc.citation.volume9
dc.citation.other9: -
dc.citation.rankM23
dc.identifier.wos000276387300001
dc.identifier.doi10.1186/1476-511X-9-27
dc.identifier.pmid20219094
dc.identifier.scopus2-s2.0-77949443771
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/286/1372.pdf
dc.identifier.rcubconv_2296
dc.type.versionpublishedVersion


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