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Evaluation of different formulas for LDL-C calculation
dc.creator | Vujović, Ana | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Spasić, Slavica | |
dc.creator | Bujisić, Nada | |
dc.creator | Martinović, Jelena | |
dc.creator | Vujović, Milica | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Pajić, Dragoljub | |
dc.date.accessioned | 2019-09-02T11:21:10Z | |
dc.date.available | 2019-09-02T11:21:10Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1476-511X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1374 | |
dc.description.abstract | Background: Friedewald's formula for the estimation of LDL-C concentration is the most often used formula in clinical practice. A recent formula by Anandaraja and colleagues for LDL-C estimation still needs to be evaluated before it is extensively applied in diagnosis. In the present study we validated existing formulas and derived a more accurate formula to determine LDL-C in a Serbian population. Methods: Our study included 2053 patients with TG lt = 4.52 mmol/L. In an initial group of 1010 patients, Friedewald's and Anandaraja's formulas were compared to a direct homogenous method for LDL-C determination. The obtained results allowed us to modify Friedewald's formula and apply it in a second group of patients. Results: The mean LDL-C concentrations were 3.9 +/- 1.09 mmol/L, 3.63 +/- 1.06 mmol/L and 3.72 +/- 1.04 mmol/L measured by a direct homogenous assay (D-LDL-C), calculated by Friedewald's formula (F-LDL-C) and calculated by Anandaraja's formula (A-LDL-C), respectively in the 1010 patients. The Student's paired t-test showed that D-LDL-C values were significantly higher than F-LDL-C and A-LDL-C values (p lt 0.001). The Passing-Bablok regression analysis indicated good correlation between calculated and measured LDL-Cs (r > 0.89). Using lipoprotein values from the initial group we modified Friedewald's formula by replacing the term 2.2 with 3. The new modified formula for LDL-C estimation (S-LDL-C) showed no statistically significant difference compared to D-LDL-C. The absolute bias between these two methods was -0.06 +/- 0.37 mmol/L with a high correlation coefficient (r = 0.96). Conclusions: Our modified formula for LDL-C estimation appears to be more accurate than both Friedewald's and Anandaraja's formulas when applied to a Serbian population. | en |
dc.publisher | BMC, LONDON | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Lipids in Health and Disease | |
dc.title | Evaluation of different formulas for LDL-C calculation | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Бујисић, Нада; Зељковић, Aлександра; Пајић, Драгољуб; Вујовић, Милица; Котур-Стевуљевић, Јелена; Спасић, Славица; Спасојевић-Калимановска, Весна; Вујовић, Aна; Мартиновић, Јелена; | |
dc.citation.volume | 9 | |
dc.citation.other | 9: - | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000276387300001 | |
dc.identifier.doi | 10.1186/1476-511X-9-27 | |
dc.identifier.pmid | 20219094 | |
dc.identifier.scopus | 2-s2.0-77949443771 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/286/1372.pdf | |
dc.type.version | publishedVersion |