Review: Cell cycle aberrations and neurodegeneration
2010
Аутори
Bonda, David J.Bajić, Vladan
Potparević, Biljana
Casadesus, G.
Zhu, Xiongwei
Smith, Mark A.
Lee, Hyoung-Gon
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The cell cycle is a highly regulated and fundamental cellular process that involves complex feedback regulation of many proteins, and any compromise to its integrity elicits dire consequences for the cell. For example, in neurodegenerative diseases such as Alzheimer disease (AD), evidence for abnormal cell cycle re-entry precedes other hallmarks of disease and as such, implicates cell cycle aberrations in the aetiology of AD. The mechanism(s) for cell cycle re-entry in AD, however, remain unclear. Current theory suggests it to be part of a combination of early events that together elicit the degenerative pathology and cognitive phenotype consistent with the disease. We propose a 'Two-Hit Hypothesis' that highlights the concerted interaction between cell cycle alterations and oxidative stress that combine to produce neurodegeneration. Here, we review the evidence implicating cell cycle mechanisms in AD and how such changes, especially in combination with oxidative stress, would lead to ...a cascade of events leading to disease. Based on this concept, we propose new opportunities for disease treatment.
Кључне речи:
Alzheimer's disease / cell cycle re-entry / mitotic insult / mitotic steady state / oxidative stressИзвор:
Neuropathology and Applied Neurobiology, 2010, 36, 2, 157-163Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- National Institutes of Health - AG028679
DOI: 10.1111/j.1365-2990.2010.01064.x
ISSN: 0305-1846
PubMed: 20059701
WoS: 000275919200005
Scopus: 2-s2.0-77949897817
Институција/група
PharmacyTY - JOUR AU - Bonda, David J. AU - Bajić, Vladan AU - Potparević, Biljana AU - Casadesus, G. AU - Zhu, Xiongwei AU - Smith, Mark A. AU - Lee, Hyoung-Gon PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1378 AB - The cell cycle is a highly regulated and fundamental cellular process that involves complex feedback regulation of many proteins, and any compromise to its integrity elicits dire consequences for the cell. For example, in neurodegenerative diseases such as Alzheimer disease (AD), evidence for abnormal cell cycle re-entry precedes other hallmarks of disease and as such, implicates cell cycle aberrations in the aetiology of AD. The mechanism(s) for cell cycle re-entry in AD, however, remain unclear. Current theory suggests it to be part of a combination of early events that together elicit the degenerative pathology and cognitive phenotype consistent with the disease. We propose a 'Two-Hit Hypothesis' that highlights the concerted interaction between cell cycle alterations and oxidative stress that combine to produce neurodegeneration. Here, we review the evidence implicating cell cycle mechanisms in AD and how such changes, especially in combination with oxidative stress, would lead to a cascade of events leading to disease. Based on this concept, we propose new opportunities for disease treatment. PB - Wiley, Hoboken T2 - Neuropathology and Applied Neurobiology T1 - Review: Cell cycle aberrations and neurodegeneration VL - 36 IS - 2 SP - 157 EP - 163 DO - 10.1111/j.1365-2990.2010.01064.x ER -
@article{ author = "Bonda, David J. and Bajić, Vladan and Potparević, Biljana and Casadesus, G. and Zhu, Xiongwei and Smith, Mark A. and Lee, Hyoung-Gon", year = "2010", abstract = "The cell cycle is a highly regulated and fundamental cellular process that involves complex feedback regulation of many proteins, and any compromise to its integrity elicits dire consequences for the cell. For example, in neurodegenerative diseases such as Alzheimer disease (AD), evidence for abnormal cell cycle re-entry precedes other hallmarks of disease and as such, implicates cell cycle aberrations in the aetiology of AD. The mechanism(s) for cell cycle re-entry in AD, however, remain unclear. Current theory suggests it to be part of a combination of early events that together elicit the degenerative pathology and cognitive phenotype consistent with the disease. We propose a 'Two-Hit Hypothesis' that highlights the concerted interaction between cell cycle alterations and oxidative stress that combine to produce neurodegeneration. Here, we review the evidence implicating cell cycle mechanisms in AD and how such changes, especially in combination with oxidative stress, would lead to a cascade of events leading to disease. Based on this concept, we propose new opportunities for disease treatment.", publisher = "Wiley, Hoboken", journal = "Neuropathology and Applied Neurobiology", title = "Review: Cell cycle aberrations and neurodegeneration", volume = "36", number = "2", pages = "157-163", doi = "10.1111/j.1365-2990.2010.01064.x" }
Bonda, D. J., Bajić, V., Potparević, B., Casadesus, G., Zhu, X., Smith, M. A.,& Lee, H.. (2010). Review: Cell cycle aberrations and neurodegeneration. in Neuropathology and Applied Neurobiology Wiley, Hoboken., 36(2), 157-163. https://doi.org/10.1111/j.1365-2990.2010.01064.x
Bonda DJ, Bajić V, Potparević B, Casadesus G, Zhu X, Smith MA, Lee H. Review: Cell cycle aberrations and neurodegeneration. in Neuropathology and Applied Neurobiology. 2010;36(2):157-163. doi:10.1111/j.1365-2990.2010.01064.x .
Bonda, David J., Bajić, Vladan, Potparević, Biljana, Casadesus, G., Zhu, Xiongwei, Smith, Mark A., Lee, Hyoung-Gon, "Review: Cell cycle aberrations and neurodegeneration" in Neuropathology and Applied Neurobiology, 36, no. 2 (2010):157-163, https://doi.org/10.1111/j.1365-2990.2010.01064.x . .