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Spectrophotometric determination of fluorometholone in pharmaceuticals using 1,4-dihydrazinophthalazine

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Authors
Vladimirov, Sote
Čudina, Olivera
Agbaba, Danica
Živanov-Stakić, Dobrila
Article (Published version)
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Abstract
A sensitive and simple spectrophotometric method for the determination of fluorometholone in pharmaceutical formulations using 1,4-dihydrazinophthalazine (1,4-DHPHT; dihydralazine) as the reagent is presented. The yellow coloured dihydralazinohydrazone of fluorometholone was obtained, after heating at 85 degrees C for 2 hrs in acidified 1-propanol as a solvent. The prepared dihydralazinophthalazone shows a maximum at 380 nm with molar absorptivity of 1.91x10(4) lmol(-1)cm(-1). Beers law is obeyed up to 12 mu g/ml of fluorometholone. The method applied for the determination of fluorometholone in pharmaceutical formulations gave precise and reproducible results; recoveries were 97.43% (RSD=2.67%) and 98.25% (RSD=2.56%) for ointment and suppositories, respectively.
Keywords:
1,4-dihydrazinophthalazine / Fluorometholone / Pharmaceuticals / Spectrophotometry
Source:
Analytical Letters, 1996, 29, 6, 921-927
Publisher:
  • Marcel Dekker Inc, New York

DOI: 10.1080/00032719608001444

ISSN: 0003-2719

WoS: A1996UJ04100006

Scopus: 2-s2.0-2742530210
[ Google Scholar ]
5
5
Handle
https://hdl.handle.net/21.15107/rcub_farfar_138
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/138
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Vladimirov, Sote
AU  - Čudina, Olivera
AU  - Agbaba, Danica
AU  - Živanov-Stakić, Dobrila
PY  - 1996
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/138
AB  - A sensitive and simple spectrophotometric method for the determination of fluorometholone in pharmaceutical formulations using 1,4-dihydrazinophthalazine (1,4-DHPHT; dihydralazine) as the reagent is presented. The yellow coloured dihydralazinohydrazone of fluorometholone was obtained, after heating at 85 degrees C for 2 hrs in acidified 1-propanol as a solvent. The prepared dihydralazinophthalazone shows a maximum at 380 nm with molar absorptivity of 1.91x10(4) lmol(-1)cm(-1). Beers law is obeyed up to 12 mu g/ml of fluorometholone. The method applied for the determination of fluorometholone in pharmaceutical formulations gave precise and reproducible results; recoveries were 97.43% (RSD=2.67%) and 98.25% (RSD=2.56%) for ointment and suppositories, respectively.
PB  - Marcel Dekker Inc, New York
T2  - Analytical Letters
T1  - Spectrophotometric determination of fluorometholone in pharmaceuticals using 1,4-dihydrazinophthalazine
VL  - 29
IS  - 6
SP  - 921
EP  - 927
DO  - 10.1080/00032719608001444
UR  - https://hdl.handle.net/21.15107/rcub_farfar_138
ER  - 
@article{
author = "Vladimirov, Sote and Čudina, Olivera and Agbaba, Danica and Živanov-Stakić, Dobrila",
year = "1996",
abstract = "A sensitive and simple spectrophotometric method for the determination of fluorometholone in pharmaceutical formulations using 1,4-dihydrazinophthalazine (1,4-DHPHT; dihydralazine) as the reagent is presented. The yellow coloured dihydralazinohydrazone of fluorometholone was obtained, after heating at 85 degrees C for 2 hrs in acidified 1-propanol as a solvent. The prepared dihydralazinophthalazone shows a maximum at 380 nm with molar absorptivity of 1.91x10(4) lmol(-1)cm(-1). Beers law is obeyed up to 12 mu g/ml of fluorometholone. The method applied for the determination of fluorometholone in pharmaceutical formulations gave precise and reproducible results; recoveries were 97.43% (RSD=2.67%) and 98.25% (RSD=2.56%) for ointment and suppositories, respectively.",
publisher = "Marcel Dekker Inc, New York",
journal = "Analytical Letters",
title = "Spectrophotometric determination of fluorometholone in pharmaceuticals using 1,4-dihydrazinophthalazine",
volume = "29",
number = "6",
pages = "921-927",
doi = "10.1080/00032719608001444",
url = "https://hdl.handle.net/21.15107/rcub_farfar_138"
}
Vladimirov, S., Čudina, O., Agbaba, D.,& Živanov-Stakić, D.. (1996). Spectrophotometric determination of fluorometholone in pharmaceuticals using 1,4-dihydrazinophthalazine. in Analytical Letters
Marcel Dekker Inc, New York., 29(6), 921-927.
https://doi.org/10.1080/00032719608001444
https://hdl.handle.net/21.15107/rcub_farfar_138
Vladimirov S, Čudina O, Agbaba D, Živanov-Stakić D. Spectrophotometric determination of fluorometholone in pharmaceuticals using 1,4-dihydrazinophthalazine. in Analytical Letters. 1996;29(6):921-927.
doi:10.1080/00032719608001444
https://hdl.handle.net/21.15107/rcub_farfar_138 .
Vladimirov, Sote, Čudina, Olivera, Agbaba, Danica, Živanov-Stakić, Dobrila, "Spectrophotometric determination of fluorometholone in pharmaceuticals using 1,4-dihydrazinophthalazine" in Analytical Letters, 29, no. 6 (1996):921-927,
https://doi.org/10.1080/00032719608001444 .,
https://hdl.handle.net/21.15107/rcub_farfar_138 .

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