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dc.creatorRadisavljević, Snežana
dc.creatorPeco-Antić, Amira
dc.creatorKotur-Stevuljević, Jelena
dc.creatorSavić, Olivera
dc.date.accessioned2019-09-02T11:21:24Z
dc.date.available2019-09-02T11:21:24Z
dc.date.issued2010
dc.identifier.issn0370-8179
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1384
dc.description.abstractIntroduction Balkan endemic nephropathy (BEN) is a familial chronic progressive tubulointerstitial disease of unknown aetiology that occurs with high prevalence in endemic rural environments of Serbia, Bosnia and Herzegovina, Croatia, Bulgaria and Romania. It has been documented only in adults. Objective The aim of this study was to examine clinical markers of BEN in children and adolescent offspring of BEN patients. Methods Prospective clinical trial involved two groups of children and adolescents: I consisted of 30 offspring of BEN patients and II of 29 offspring of non-BEN dialysis patients, both of them living in the same South Morava region of Serbia. All of them were healthy at the time of the investigation, not receiving any drugs. The study included personal and family history, physical examination, comprehensive laboratory analyses and renal ultrasound. Blood pressure (BP) was determined by using casual BP and 24 h ABPM in subjects older than 5 years. Urinary proteins were investigated by analysing microalbumin, alfa 1 microglobulin, beta 2 rnicroglobulin and SDS-PAGE electrophoresis. GFR was measured by estimated creatinine clearance and by serum Cystatin C concentrations. Results There were no statistically significant differences in age, gender, history of urinary tract infections or functional voiding disorders between these two groups. All of the studied subjects had normal BP and GFR. Renal ultrasound was abnormal only in BEN offspring (6.66%) as well as increased urine concentrations of microalbumin (3.3%), alpha 1 microglobulin (10%) and beta 2 microglobulin (13.3%) while low molecular protein ( lt 66,000 D) was prevalent in BEN compared with non-BEN offspring (21.43% vs. 3.7%). Conclusion Renal abnormalities in offspring of BEN patients may be an early marker of BEN. This has to be confirmed in long term follow-up of a greater number of BEN paediatric offspring.en
dc.publisherSrpsko lekarsko društvo, Beograd
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceSrpski arhiv za celokupno lekarstvo
dc.subjectendemic nephropathyen
dc.subjectproteinuriaen
dc.subjectbeta 2 microglobulinsen
dc.subjectalpha 1 microglobulinsen
dc.titleStructural and Functional Characteristics of Urinary Tract in Offspring of Balkan Endemic Nephropathy Patientsen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractРадисављевић, Снежана; Савић, Оливера; Котур-Стевуљевић, Јелена; Пецо-Aнтић, Aмира;
dc.citation.volume138
dc.citation.issue3-4
dc.citation.spage204
dc.citation.epage209
dc.citation.other138(3-4): 204-209
dc.citation.rankM23
dc.identifier.wos000277486200012
dc.identifier.doi10.2298/SARH1004204R
dc.identifier.pmid20499501
dc.identifier.scopus2-s2.0-77953509467
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/295/1382.pdf
dc.type.versionpublishedVersion


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