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dc.creatorDragičević-Curić, Nina
dc.creatorWinter, Sven
dc.creatorKrajišnik, Danina
dc.creatorStupar, Mirjana
dc.creatorMilić, Jela
dc.creatorGraefe, Susanna
dc.creatorFahr, Alfred
dc.date.accessioned2019-09-02T11:21:26Z
dc.date.available2019-09-02T11:21:26Z
dc.date.issued2010
dc.identifier.issn0898-2104
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1386
dc.description.abstractTemoporfin (mTHPC) is a potent second-generation synthetic photosensitizer. Topical delivery of mTHPC is of great interest for the photodynamic therapy of psoriasis and superficial skin cancer lesions. The aim of this study was to evaluate the stability of hydrophilic gels containing mTHPC-loaded liposomes. Two different mTHPC-loaded liposome dispersions, composed of 15 % (w/w) nonhydrogenated soybean lecithin of different phosphatidylcholine content, were prepared and incorporated (2:1 w/w) into hydrogels of different carbomer concentrations (1.5, 2.25, and 3%; w/w). Obtained liposomal hydrogels, containing 0.15% (w/w) mTHPC, 10% (w/w) phospholipids, and 0, 0.5, or 1% (w/w) carbomer, were analyzed for flow properties, liposome particle size, and polydispersity index (PDI), pH value, and mTHPC content after their preparation and at predetermined time intervals during 6 months of storage at 4 and 23 degrees C. All hydrogels showed, during the whole period of investigation, adequate characteristics for topical application (i.e., they revealed shear-thinning plastic flow behavior). Rheological parameters, particle size, and PDI of liposomes in hydrogels, mTHPC content, and pH value did not show remarkable changes during the storage of gels, which could make them unacceptable for topical use. The obtained results indicated physical and chemical stability of liposomal gels containing mTHPC during 6 months of storage at both temperatures.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationbiolitec AG
dc.relationGerman Academic Exchange Service (DAAD)
dc.rightsrestrictedAccess
dc.sourceJournal of Liposome Research
dc.subjectTemoporfinen
dc.subjectliposomeen
dc.subjectliposomal hydrogelen
dc.subjectstabilityen
dc.subjectcarbomeren
dc.subjectrheologyen
dc.titleStability evaluation of temoporfin-loaded liposomal gels for topical applicationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилић, Јела; Ступар, Мирјана; Wинтер, Свен; Крајишник, Данина; Драгичевић-Цурић, Нина; Граефе, Сусанна; Фахр, Aлфред;
dc.citation.volume20
dc.citation.issue1
dc.citation.spage38
dc.citation.epage48
dc.citation.other20(1): 38-48
dc.citation.rankM23
dc.identifier.wos000274879200006
dc.identifier.doi10.3109/08982100903030263
dc.identifier.pmid19558347
dc.identifier.scopus2-s2.0-77149141801
dc.identifier.rcubconv_2280
dc.type.versionpublishedVersion


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