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Forced degradation studies of simvastatin using microemulsion liquid chromatography

Authorized Users Only
2010
Authors
Malenović, Anđelija
Jančić-Stojanović, Biljana
Ivanović, Darko
Medenica, Mirjana
Article (Published version)
Metadata
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Abstract
In this paper, the definition of simvastatin degradation profile by microemulsion liquid chromatography (MELC) is presented. The aim of the study was to investigate simvastatin stability after various stress tests, such as: acid and base hydrolysis, oxidation, and heat. The kinetics of acid and oxidative degradation was also studied. The complex retention mechanism occurring when microemulsion is used as eluent enabled the successful separation of a large number of degradants in prepared stress samples. The existence of a second partitioning site due to microstructural and interfacial characteristics of o/w microemulsion eluent facilitated HPLC separation. All the expected capabilities of MELC method were realized, demonstrating the advantage and value of the MELC method for a wide area of pharmaceutical analysis. For acid degradation the second order rate constant and half-life were calculated. Oxidative decomposition proved to be the first order reaction for which the rate constant a...nd half-life were also determined.

Keywords:
forced degradation studies / kinetic study / microemulsion liquid chromatography / simvastatin
Source:
Journal of Liquid Chromatography & Related Technologies, 2010, 33, 4, 536-547
Publisher:
  • Taylor & Francis Inc, Philadelphia
Funding / projects:
  • Formulisanje i Karakterizacija separacionih sistema za modelovanje retencionog ponašanja lekovitih supstancija uz hemometrijsku evaluaciju (RS-142077)

DOI: 10.1080/10826070903574576

ISSN: 1082-6076

WoS: 000274536100011

Scopus: 2-s2.0-76749098168
[ Google Scholar ]
16
11
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1389
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Malenović, Anđelija
AU  - Jančić-Stojanović, Biljana
AU  - Ivanović, Darko
AU  - Medenica, Mirjana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1389
AB  - In this paper, the definition of simvastatin degradation profile by microemulsion liquid chromatography (MELC) is presented. The aim of the study was to investigate simvastatin stability after various stress tests, such as: acid and base hydrolysis, oxidation, and heat. The kinetics of acid and oxidative degradation was also studied. The complex retention mechanism occurring when microemulsion is used as eluent enabled the successful separation of a large number of degradants in prepared stress samples. The existence of a second partitioning site due to microstructural and interfacial characteristics of o/w microemulsion eluent facilitated HPLC separation. All the expected capabilities of MELC method were realized, demonstrating the advantage and value of the MELC method for a wide area of pharmaceutical analysis. For acid degradation the second order rate constant and half-life were calculated. Oxidative decomposition proved to be the first order reaction for which the rate constant and half-life were also determined.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Forced degradation studies of simvastatin using microemulsion liquid chromatography
VL  - 33
IS  - 4
SP  - 536
EP  - 547
DO  - 10.1080/10826070903574576
ER  - 
@article{
author = "Malenović, Anđelija and Jančić-Stojanović, Biljana and Ivanović, Darko and Medenica, Mirjana",
year = "2010",
abstract = "In this paper, the definition of simvastatin degradation profile by microemulsion liquid chromatography (MELC) is presented. The aim of the study was to investigate simvastatin stability after various stress tests, such as: acid and base hydrolysis, oxidation, and heat. The kinetics of acid and oxidative degradation was also studied. The complex retention mechanism occurring when microemulsion is used as eluent enabled the successful separation of a large number of degradants in prepared stress samples. The existence of a second partitioning site due to microstructural and interfacial characteristics of o/w microemulsion eluent facilitated HPLC separation. All the expected capabilities of MELC method were realized, demonstrating the advantage and value of the MELC method for a wide area of pharmaceutical analysis. For acid degradation the second order rate constant and half-life were calculated. Oxidative decomposition proved to be the first order reaction for which the rate constant and half-life were also determined.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Forced degradation studies of simvastatin using microemulsion liquid chromatography",
volume = "33",
number = "4",
pages = "536-547",
doi = "10.1080/10826070903574576"
}
Malenović, A., Jančić-Stojanović, B., Ivanović, D.,& Medenica, M.. (2010). Forced degradation studies of simvastatin using microemulsion liquid chromatography. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 33(4), 536-547.
https://doi.org/10.1080/10826070903574576
Malenović A, Jančić-Stojanović B, Ivanović D, Medenica M. Forced degradation studies of simvastatin using microemulsion liquid chromatography. in Journal of Liquid Chromatography & Related Technologies. 2010;33(4):536-547.
doi:10.1080/10826070903574576 .
Malenović, Anđelija, Jančić-Stojanović, Biljana, Ivanović, Darko, Medenica, Mirjana, "Forced degradation studies of simvastatin using microemulsion liquid chromatography" in Journal of Liquid Chromatography & Related Technologies, 33, no. 4 (2010):536-547,
https://doi.org/10.1080/10826070903574576 . .

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