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dc.creatorPerović, Bojana
dc.creatorJovanović, Marija
dc.creatorMiljković, Branislava
dc.creatorVezmar, Sandra
dc.date.accessioned2019-09-02T11:21:33Z
dc.date.available2019-09-02T11:21:33Z
dc.date.issued2010
dc.identifier.issn1178-2021
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1392
dc.description.abstractMajor depressive disorder (MDD) is a common and serious illness of our times, associated with monoamine deficiency in the brain. Moreover, increased levels of cortisol, possibly caused by stress, may be related to depression. In the treatment of MDD, the use of older antidepressants such as monoamine oxidase inhibitors and tricyclic antidepressants is decreasing rapidly, mainly due to their adverse effect profiles. In contrast, the use of serotonin reuptake inhibitors and newer antidepressants, which have dual modes of action such as inhibition of the serotonin and noradrenaline or dopamine reuptake, is increasing. Novel antidepressants have additive modes of action such as agomelatine, a potent agonist of melatonin receptors. Drugs in development for treatment of MDD include triple reuptake inhibitors, dual-acting serotonin reuptake inhibitors and histamine antagonists, and many more. Newer antidepressants have similar efficacy and in general good tolerability profiles. Nevertheless, compliance with treatment for MDD is poor and may contribute to treatment failure. Despite the broad spectrum of available antidepressants, there are still at least 30% of depressive patients who do not benefit from treatment. Therefore, new approaches in drug development are necessary and, according to current research developments, the future of antidepressant treatment may be promising.en
dc.publisherDove Medical Press Ltd, Albany
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145001/RS//
dc.rightsopenAccess
dc.sourceNeuropsychiatric Disease and Treatment
dc.subjectmajor depressive disordersen
dc.subjectmonoamine deficiencyen
dc.subjectantidepressantsen
dc.subjectdepressionen
dc.titleGetting the balance right: Established and emerging therapies for major depressive disordersen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractПеровић, Бојана; Везмар, Сандра; Јовановић, Марија; Миљковић, Бранислава;
dc.citation.volume6
dc.citation.spage343
dc.citation.epage364
dc.citation.other6: 343-364
dc.identifier.wos000294953300037
dc.identifier.pmid20856599
dc.identifier.rcubconv_2517
dc.type.versionpublishedVersion


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