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Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid

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2010
Authors
Tasić-Kostov, Marija
Savić, Snežana
Lukić, Milica
Tamburić, Slobodanka
Pavlović, Miloš
Vuleta, Gordana
Article (Published version)
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Abstract
Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles - gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated. Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks. Results/conclusion LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation an...d skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals.

Keywords:
lactobionic acid / glycolic acid / safety / cosmeceuticals / emulsifiers / bioengineering of the skin
Source:
Journal of Cosmetic Dermatology, 2010, 9, 1, 3-10
Publisher:
  • Wiley Periodicals, Inc, Malden

DOI: 10.1111/j.1473-2165.2010.00474.x

ISSN: 1473-2130

PubMed: 20367666

WoS: 000298181500002

Scopus: 2-s2.0-77954366536
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1393
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Pharmacy

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