Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
Само за регистроване кориснике
2010
Аутори
Tasić-Kostov, MarijaSavić, Snežana
Lukić, Milica
Tamburić, Slobodanka
Pavlović, Miloš
Vuleta, Gordana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles - gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated. Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks. Results/conclusion LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation an...d skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals.
Кључне речи:
lactobionic acid / glycolic acid / safety / cosmeceuticals / emulsifiers / bioengineering of the skinИзвор:
Journal of Cosmetic Dermatology, 2010, 9, 1, 3-10Издавач:
- Wiley Periodicals, Inc, Malden
DOI: 10.1111/j.1473-2165.2010.00474.x
ISSN: 1473-2130
PubMed: 20367666
WoS: 000298181500002
Scopus: 2-s2.0-77954366536
Институција/група
PharmacyTY - JOUR AU - Tasić-Kostov, Marija AU - Savić, Snežana AU - Lukić, Milica AU - Tamburić, Slobodanka AU - Pavlović, Miloš AU - Vuleta, Gordana PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1393 AB - Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles - gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated. Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks. Results/conclusion LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals. PB - Wiley Periodicals, Inc, Malden T2 - Journal of Cosmetic Dermatology T1 - Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid VL - 9 IS - 1 SP - 3 EP - 10 DO - 10.1111/j.1473-2165.2010.00474.x ER -
@article{ author = "Tasić-Kostov, Marija and Savić, Snežana and Lukić, Milica and Tamburić, Slobodanka and Pavlović, Miloš and Vuleta, Gordana", year = "2010", abstract = "Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles - gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated. Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks. Results/conclusion LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals.", publisher = "Wiley Periodicals, Inc, Malden", journal = "Journal of Cosmetic Dermatology", title = "Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid", volume = "9", number = "1", pages = "3-10", doi = "10.1111/j.1473-2165.2010.00474.x" }
Tasić-Kostov, M., Savić, S., Lukić, M., Tamburić, S., Pavlović, M.,& Vuleta, G.. (2010). Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid. in Journal of Cosmetic Dermatology Wiley Periodicals, Inc, Malden., 9(1), 3-10. https://doi.org/10.1111/j.1473-2165.2010.00474.x
Tasić-Kostov M, Savić S, Lukić M, Tamburić S, Pavlović M, Vuleta G. Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid. in Journal of Cosmetic Dermatology. 2010;9(1):3-10. doi:10.1111/j.1473-2165.2010.00474.x .
Tasić-Kostov, Marija, Savić, Snežana, Lukić, Milica, Tamburić, Slobodanka, Pavlović, Miloš, Vuleta, Gordana, "Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid" in Journal of Cosmetic Dermatology, 9, no. 1 (2010):3-10, https://doi.org/10.1111/j.1473-2165.2010.00474.x . .