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dc.creatorTasić-Kostov, Marija
dc.creatorSavić, Snežana
dc.creatorLukić, Milica
dc.creatorTamburić, Slobodanka
dc.creatorPavlović, Miloš
dc.creatorVuleta, Gordana
dc.date.accessioned2019-09-02T11:21:37Z
dc.date.available2019-09-02T11:21:37Z
dc.date.issued2010
dc.identifier.issn1473-2130
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1393
dc.description.abstractBackground/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles - gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated. Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks. Results/conclusion LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals.en
dc.publisherWiley Periodicals, Inc, Malden
dc.rightsrestrictedAccess
dc.sourceJournal of Cosmetic Dermatology
dc.subjectlactobionic aciden
dc.subjectglycolic aciden
dc.subjectsafetyen
dc.subjectcosmeceuticalsen
dc.subjectemulsifiersen
dc.subjectbioengineering of the skinen
dc.titleLactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic aciden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВулета, Гордана; Савић, Снежана; Лукић, Милица; Павловић, Милош; Тамбурић, Слободанка; Тасић-Костов, Марија;
dc.citation.volume9
dc.citation.issue1
dc.citation.spage3
dc.citation.epage10
dc.citation.other9(1): 3-10
dc.identifier.wos000298181500002
dc.identifier.doi10.1111/j.1473-2165.2010.00474.x
dc.identifier.pmid20367666
dc.identifier.scopus2-s2.0-77954366536
dc.identifier.rcubconv_2566
dc.type.versionpublishedVersion


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