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Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
dc.creator | Tasić-Kostov, Marija | |
dc.creator | Savić, Snežana | |
dc.creator | Lukić, Milica | |
dc.creator | Tamburić, Slobodanka | |
dc.creator | Pavlović, Miloš | |
dc.creator | Vuleta, Gordana | |
dc.date.accessioned | 2019-09-02T11:21:37Z | |
dc.date.available | 2019-09-02T11:21:37Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1473-2130 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1393 | |
dc.description.abstract | Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles - gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated. Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks. Results/conclusion LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals. | en |
dc.publisher | Wiley Periodicals, Inc, Malden | |
dc.rights | restrictedAccess | |
dc.source | Journal of Cosmetic Dermatology | |
dc.subject | lactobionic acid | en |
dc.subject | glycolic acid | en |
dc.subject | safety | en |
dc.subject | cosmeceuticals | en |
dc.subject | emulsifiers | en |
dc.subject | bioengineering of the skin | en |
dc.title | Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вулета, Гордана; Савић, Снежана; Лукић, Милица; Павловић, Милош; Тамбурић, Слободанка; Тасић-Костов, Марија; | |
dc.citation.volume | 9 | |
dc.citation.issue | 1 | |
dc.citation.spage | 3 | |
dc.citation.epage | 10 | |
dc.citation.other | 9(1): 3-10 | |
dc.identifier.wos | 000298181500002 | |
dc.identifier.doi | 10.1111/j.1473-2165.2010.00474.x | |
dc.identifier.pmid | 20367666 | |
dc.identifier.scopus | 2-s2.0-77954366536 | |
dc.type.version | publishedVersion |