Knowledge of druglike properties, such as dissociation constants (pK(a)), is of great importance in drug development and analysis. However, poor aqueous Solubility often Causes serious limitations ill accurate determination of a drug's pK(a). In this Study, the apparent dissociation constant (pK(a)') of the poorly soluble drug, glimepiride, has been determined by application of the spectrophotometric and Solubility methods. Compared to the literature reported glimepiride pK(a)' values of 4.99 +/- 0.50 and 6.2 +/- 0.1, the values obtained in the present study were 8.07 +/- 0.02 and 7.26 +/- 0.01 determined by the spectrophotometric and Solubility method, respectively. In addition, the advantages of these two methods in pK(a)' determination of glimepiride are discussed.
Source:
Journal of Chemical and Engineering Data, 2010, 55, 3, 1368-1371
TY - JOUR
AU - Cvijić, Sandra
AU - Parojčić, Jelena
AU - Malenović, Anđelija
AU - Đurić, Zorica
AU - Maksimović, Milica
PY - 2010
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1395
AB - Knowledge of druglike properties, such as dissociation constants (pK(a)), is of great importance in drug development and analysis. However, poor aqueous Solubility often Causes serious limitations ill accurate determination of a drug's pK(a). In this Study, the apparent dissociation constant (pK(a)') of the poorly soluble drug, glimepiride, has been determined by application of the spectrophotometric and Solubility methods. Compared to the literature reported glimepiride pK(a)' values of 4.99 +/- 0.50 and 6.2 +/- 0.1, the values obtained in the present study were 8.07 +/- 0.02 and 7.26 +/- 0.01 determined by the spectrophotometric and Solubility method, respectively. In addition, the advantages of these two methods in pK(a)' determination of glimepiride are discussed.
PB - Amer Chemical Soc, Washington
T2 - Journal of Chemical and Engineering Data
T1 - A Contribution to the Glimepiride Dissociation Constant Determination
VL - 55
IS - 3
SP - 1368
EP - 1371
DO - 10.1021/je900546z
ER -
@article{
author = "Cvijić, Sandra and Parojčić, Jelena and Malenović, Anđelija and Đurić, Zorica and Maksimović, Milica",
year = "2010",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1395",
abstract = "Knowledge of druglike properties, such as dissociation constants (pK(a)), is of great importance in drug development and analysis. However, poor aqueous Solubility often Causes serious limitations ill accurate determination of a drug's pK(a). In this Study, the apparent dissociation constant (pK(a)') of the poorly soluble drug, glimepiride, has been determined by application of the spectrophotometric and Solubility methods. Compared to the literature reported glimepiride pK(a)' values of 4.99 +/- 0.50 and 6.2 +/- 0.1, the values obtained in the present study were 8.07 +/- 0.02 and 7.26 +/- 0.01 determined by the spectrophotometric and Solubility method, respectively. In addition, the advantages of these two methods in pK(a)' determination of glimepiride are discussed.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Chemical and Engineering Data",
title = "A Contribution to the Glimepiride Dissociation Constant Determination",
volume = "55",
number = "3",
pages = "1368-1371",
doi = "10.1021/je900546z"
}
Cvijić S, Parojčić J, Malenović A, Đurić Z, Maksimović M. A Contribution to the Glimepiride Dissociation Constant Determination. Journal of Chemical and Engineering Data. 2010;55(3):1368-1371
Cvijić, S., Parojčić, J., Malenović, A., Đurić, Z.,& Maksimović, M. (2010). A Contribution to the Glimepiride Dissociation Constant Determination.
Journal of Chemical and Engineering DataAmer Chemical Soc, Washington., 55(3), 1368-1371.
https://doi.org/10.1021/je900546z
Cvijić Sandra, Parojčić Jelena, Malenović Anđelija, Đurić Zorica, Maksimović Milica, "A Contribution to the Glimepiride Dissociation Constant Determination" 55, no. 3 (2010):1368-1371,
https://doi.org/10.1021/je900546z .
