A Contribution to the Glimepiride Dissociation Constant Determination
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2010
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Knowledge of druglike properties, such as dissociation constants (pK(a)), is of great importance in drug development and analysis. However, poor aqueous Solubility often Causes serious limitations ill accurate determination of a drug's pK(a). In this Study, the apparent dissociation constant (pK(a)') of the poorly soluble drug, glimepiride, has been determined by application of the spectrophotometric and Solubility methods. Compared to the literature reported glimepiride pK(a)' values of 4.99 +/- 0.50 and 6.2 +/- 0.1, the values obtained in the present study were 8.07 +/- 0.02 and 7.26 +/- 0.01 determined by the spectrophotometric and Solubility method, respectively. In addition, the advantages of these two methods in pK(a)' determination of glimepiride are discussed.
Izvor:
Journal of Chemical and Engineering Data, 2010, 55, 3, 1368-1371Izdavač:
- Amer Chemical Soc, Washington
Finansiranje / projekti:
DOI: 10.1021/je900546z
ISSN: 0021-9568
WoS: 000275328000052
Scopus: 2-s2.0-77949446544
Institucija/grupa
PharmacyTY - JOUR AU - Cvijić, Sandra AU - Parojčić, Jelena AU - Malenović, Anđelija AU - Đurić, Zorica AU - Maksimović, Milica PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1395 AB - Knowledge of druglike properties, such as dissociation constants (pK(a)), is of great importance in drug development and analysis. However, poor aqueous Solubility often Causes serious limitations ill accurate determination of a drug's pK(a). In this Study, the apparent dissociation constant (pK(a)') of the poorly soluble drug, glimepiride, has been determined by application of the spectrophotometric and Solubility methods. Compared to the literature reported glimepiride pK(a)' values of 4.99 +/- 0.50 and 6.2 +/- 0.1, the values obtained in the present study were 8.07 +/- 0.02 and 7.26 +/- 0.01 determined by the spectrophotometric and Solubility method, respectively. In addition, the advantages of these two methods in pK(a)' determination of glimepiride are discussed. PB - Amer Chemical Soc, Washington T2 - Journal of Chemical and Engineering Data T1 - A Contribution to the Glimepiride Dissociation Constant Determination VL - 55 IS - 3 SP - 1368 EP - 1371 DO - 10.1021/je900546z ER -
@article{ author = "Cvijić, Sandra and Parojčić, Jelena and Malenović, Anđelija and Đurić, Zorica and Maksimović, Milica", year = "2010", abstract = "Knowledge of druglike properties, such as dissociation constants (pK(a)), is of great importance in drug development and analysis. However, poor aqueous Solubility often Causes serious limitations ill accurate determination of a drug's pK(a). In this Study, the apparent dissociation constant (pK(a)') of the poorly soluble drug, glimepiride, has been determined by application of the spectrophotometric and Solubility methods. Compared to the literature reported glimepiride pK(a)' values of 4.99 +/- 0.50 and 6.2 +/- 0.1, the values obtained in the present study were 8.07 +/- 0.02 and 7.26 +/- 0.01 determined by the spectrophotometric and Solubility method, respectively. In addition, the advantages of these two methods in pK(a)' determination of glimepiride are discussed.", publisher = "Amer Chemical Soc, Washington", journal = "Journal of Chemical and Engineering Data", title = "A Contribution to the Glimepiride Dissociation Constant Determination", volume = "55", number = "3", pages = "1368-1371", doi = "10.1021/je900546z" }
Cvijić, S., Parojčić, J., Malenović, A., Đurić, Z.,& Maksimović, M.. (2010). A Contribution to the Glimepiride Dissociation Constant Determination. in Journal of Chemical and Engineering Data Amer Chemical Soc, Washington., 55(3), 1368-1371. https://doi.org/10.1021/je900546z
Cvijić S, Parojčić J, Malenović A, Đurić Z, Maksimović M. A Contribution to the Glimepiride Dissociation Constant Determination. in Journal of Chemical and Engineering Data. 2010;55(3):1368-1371. doi:10.1021/je900546z .
Cvijić, Sandra, Parojčić, Jelena, Malenović, Anđelija, Đurić, Zorica, Maksimović, Milica, "A Contribution to the Glimepiride Dissociation Constant Determination" in Journal of Chemical and Engineering Data, 55, no. 3 (2010):1368-1371, https://doi.org/10.1021/je900546z . .