Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy
Апстракт
The influence of the Li and Na salts of 12-tungstophosphoric acid H3P W12O40(WPA) was tested for in vitro effects on blood coagulation. It was found that only Li3WPA shows anticoagulant effects, but compared with WPA activity, the activity of Li salt is diminished. IR spectroscopy was used to define the reaction between these salts, and coagulation proteins. The appearance of bands characteristic of oxonium ion (H3O+) in the IR spectra indicates blocking of the active center of the protein through a very strong hydrogen bond.
Кључне речи:
Anticoagulant effect / Hydrogen bond / IR spectra / Tungstophosphoric acid saltsИзвор:
Journal of the Serbian Chemical Society, 1996, 61, 9, 767-771Издавач:
- Srpsko hemijsko društvo, Beograd
Институција/група
PharmacyTY - JOUR AU - Mioč, Ubavka B. AU - Kuntić, Vesna AU - Nedić, Zoran P. AU - Filipović, I.M AU - Jelić, S.B PY - 1996 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/141 AB - The influence of the Li and Na salts of 12-tungstophosphoric acid H3P W12O40(WPA) was tested for in vitro effects on blood coagulation. It was found that only Li3WPA shows anticoagulant effects, but compared with WPA activity, the activity of Li salt is diminished. IR spectroscopy was used to define the reaction between these salts, and coagulation proteins. The appearance of bands characteristic of oxonium ion (H3O+) in the IR spectra indicates blocking of the active center of the protein through a very strong hydrogen bond. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy VL - 61 IS - 9 SP - 767 EP - 771 UR - https://hdl.handle.net/21.15107/rcub_farfar_141 ER -
@article{ author = "Mioč, Ubavka B. and Kuntić, Vesna and Nedić, Zoran P. and Filipović, I.M and Jelić, S.B", year = "1996", abstract = "The influence of the Li and Na salts of 12-tungstophosphoric acid H3P W12O40(WPA) was tested for in vitro effects on blood coagulation. It was found that only Li3WPA shows anticoagulant effects, but compared with WPA activity, the activity of Li salt is diminished. IR spectroscopy was used to define the reaction between these salts, and coagulation proteins. The appearance of bands characteristic of oxonium ion (H3O+) in the IR spectra indicates blocking of the active center of the protein through a very strong hydrogen bond.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy", volume = "61", number = "9", pages = "767-771", url = "https://hdl.handle.net/21.15107/rcub_farfar_141" }
Mioč, U. B., Kuntić, V., Nedić, Z. P., Filipović, I.M,& Jelić, S.B. (1996). Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 61(9), 767-771. https://hdl.handle.net/21.15107/rcub_farfar_141
Mioč UB, Kuntić V, Nedić ZP, Filipović I, Jelić S. Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy. in Journal of the Serbian Chemical Society. 1996;61(9):767-771. https://hdl.handle.net/21.15107/rcub_farfar_141 .
Mioč, Ubavka B., Kuntić, Vesna, Nedić, Zoran P., Filipović, I.M, Jelić, S.B, "Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy" in Journal of the Serbian Chemical Society, 61, no. 9 (1996):767-771, https://hdl.handle.net/21.15107/rcub_farfar_141 .