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LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality

Authorized Users Only
2010
Authors
Zeljković, Aleksandra
Vekić, Jelena
Spasojević-Kalimanovska, Vesna
Jelić-Ivanović, Zorana
Bogavac-Stanojević, Nataša
Gulan, Brankica
Spasić, Slavica
Article (Published version)
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Abstract
Objective: Small, dense low-density lipoprotein (sdLDL) and small-sized high-density lipoprotein (HDL) particles are established risk factors for ischemic heart disease. However, their clinical significance for acute ischemic stroke (AIS) is uncertain. This study evaluates associations of LDL and HDL particle sizes and subclasses with AIS risk and short-term mortality after AIS. Methods: Two hundred AIS patients hospitalised for first-in-a-lifetime stroke and 162 apparently healthy controls were included in the study. LDL and HDL particles were separated by gradient gel electrophoresis and serum lipid parameters were measured by standard laboratory methods. Baseline characteristics of LDL and HDL particles were evaluated for the prediction of AIS and short-term mortality after AIS. Results: AIS patients had significantly more LDL III and IVb, but less LDL I and II particles. They also had significantly smaller HDL size, more HDL 3a, 3b and 3c and less HDL 2b subclasses. The relative co...ntent of both sdLDL and small-sized HDL particles was significantly increased in patients (P lt 0.001 and P lt 0.001, respectively). In addition, sdLDL was significantly higher in AIS fatalities (n = 25) compared with survivors (n = 175, P lt 0.05). Increased sdLDL was a significant predictor of AIS (OR = 4.31; P lt 0.001) and in-hospital mortality after AIS (OR = 5.50; P lt 0.05). The observed relationships persisted after adjustment for conventional risk factors. Conclusions: AIS is associated with adverse distributions of LDL and HDL subclasses. In addition, short-term mortality after AIS is associated with increased sdLDL particles. Our results indicate that sdLDL is an independent predictor of both AIS onset and consecutive short-term mortality.

Keywords:
Cerebrovascular disease / Stroke / Outcome / Small, dense LDL / HDL subclasses
Source:
Atherosclerosis, 2010, 210, 2, 548-554
Publisher:
  • Elsevier Ireland Ltd, Clare
Funding / projects:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.atherosclerosis.2009.11.040

ISSN: 0021-9150

PubMed: 20022325

WoS: 000278036800038

Scopus: 2-s2.0-77953231797
[ Google Scholar ]
99
81
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1415
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Bogavac-Stanojević, Nataša
AU  - Gulan, Brankica
AU  - Spasić, Slavica
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1415
AB  - Objective: Small, dense low-density lipoprotein (sdLDL) and small-sized high-density lipoprotein (HDL) particles are established risk factors for ischemic heart disease. However, their clinical significance for acute ischemic stroke (AIS) is uncertain. This study evaluates associations of LDL and HDL particle sizes and subclasses with AIS risk and short-term mortality after AIS. Methods: Two hundred AIS patients hospitalised for first-in-a-lifetime stroke and 162 apparently healthy controls were included in the study. LDL and HDL particles were separated by gradient gel electrophoresis and serum lipid parameters were measured by standard laboratory methods. Baseline characteristics of LDL and HDL particles were evaluated for the prediction of AIS and short-term mortality after AIS. Results: AIS patients had significantly more LDL III and IVb, but less LDL I and II particles. They also had significantly smaller HDL size, more HDL 3a, 3b and 3c and less HDL 2b subclasses. The relative content of both sdLDL and small-sized HDL particles was significantly increased in patients (P  lt  0.001 and P  lt  0.001, respectively). In addition, sdLDL was significantly higher in AIS fatalities (n = 25) compared with survivors (n = 175, P  lt  0.05). Increased sdLDL was a significant predictor of AIS (OR = 4.31; P  lt  0.001) and in-hospital mortality after AIS (OR = 5.50; P  lt  0.05). The observed relationships persisted after adjustment for conventional risk factors. Conclusions: AIS is associated with adverse distributions of LDL and HDL subclasses. In addition, short-term mortality after AIS is associated with increased sdLDL particles. Our results indicate that sdLDL is an independent predictor of both AIS onset and consecutive short-term mortality.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality
VL  - 210
IS  - 2
SP  - 548
EP  - 554
DO  - 10.1016/j.atherosclerosis.2009.11.040
ER  - 
@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Bogavac-Stanojević, Nataša and Gulan, Brankica and Spasić, Slavica",
year = "2010",
abstract = "Objective: Small, dense low-density lipoprotein (sdLDL) and small-sized high-density lipoprotein (HDL) particles are established risk factors for ischemic heart disease. However, their clinical significance for acute ischemic stroke (AIS) is uncertain. This study evaluates associations of LDL and HDL particle sizes and subclasses with AIS risk and short-term mortality after AIS. Methods: Two hundred AIS patients hospitalised for first-in-a-lifetime stroke and 162 apparently healthy controls were included in the study. LDL and HDL particles were separated by gradient gel electrophoresis and serum lipid parameters were measured by standard laboratory methods. Baseline characteristics of LDL and HDL particles were evaluated for the prediction of AIS and short-term mortality after AIS. Results: AIS patients had significantly more LDL III and IVb, but less LDL I and II particles. They also had significantly smaller HDL size, more HDL 3a, 3b and 3c and less HDL 2b subclasses. The relative content of both sdLDL and small-sized HDL particles was significantly increased in patients (P  lt  0.001 and P  lt  0.001, respectively). In addition, sdLDL was significantly higher in AIS fatalities (n = 25) compared with survivors (n = 175, P  lt  0.05). Increased sdLDL was a significant predictor of AIS (OR = 4.31; P  lt  0.001) and in-hospital mortality after AIS (OR = 5.50; P  lt  0.05). The observed relationships persisted after adjustment for conventional risk factors. Conclusions: AIS is associated with adverse distributions of LDL and HDL subclasses. In addition, short-term mortality after AIS is associated with increased sdLDL particles. Our results indicate that sdLDL is an independent predictor of both AIS onset and consecutive short-term mortality.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality",
volume = "210",
number = "2",
pages = "548-554",
doi = "10.1016/j.atherosclerosis.2009.11.040"
}
Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Bogavac-Stanojević, N., Gulan, B.,& Spasić, S.. (2010). LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 210(2), 548-554.
https://doi.org/10.1016/j.atherosclerosis.2009.11.040
Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Bogavac-Stanojević N, Gulan B, Spasić S. LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality. in Atherosclerosis. 2010;210(2):548-554.
doi:10.1016/j.atherosclerosis.2009.11.040 .
Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Bogavac-Stanojević, Nataša, Gulan, Brankica, Spasić, Slavica, "LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality" in Atherosclerosis, 210, no. 2 (2010):548-554,
https://doi.org/10.1016/j.atherosclerosis.2009.11.040 . .

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