LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality
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2010
Authors
Zeljković, Aleksandra
Vekić, Jelena

Spasojević-Kalimanovska, Vesna

Jelić-Ivanović, Zorana

Bogavac-Stanojević, Nataša

Gulan, Brankica
Spasić, Slavica
Article (Published version)

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Objective: Small, dense low-density lipoprotein (sdLDL) and small-sized high-density lipoprotein (HDL) particles are established risk factors for ischemic heart disease. However, their clinical significance for acute ischemic stroke (AIS) is uncertain. This study evaluates associations of LDL and HDL particle sizes and subclasses with AIS risk and short-term mortality after AIS. Methods: Two hundred AIS patients hospitalised for first-in-a-lifetime stroke and 162 apparently healthy controls were included in the study. LDL and HDL particles were separated by gradient gel electrophoresis and serum lipid parameters were measured by standard laboratory methods. Baseline characteristics of LDL and HDL particles were evaluated for the prediction of AIS and short-term mortality after AIS. Results: AIS patients had significantly more LDL III and IVb, but less LDL I and II particles. They also had significantly smaller HDL size, more HDL 3a, 3b and 3c and less HDL 2b subclasses. The relative co...ntent of both sdLDL and small-sized HDL particles was significantly increased in patients (P lt 0.001 and P lt 0.001, respectively). In addition, sdLDL was significantly higher in AIS fatalities (n = 25) compared with survivors (n = 175, P lt 0.05). Increased sdLDL was a significant predictor of AIS (OR = 4.31; P lt 0.001) and in-hospital mortality after AIS (OR = 5.50; P lt 0.05). The observed relationships persisted after adjustment for conventional risk factors. Conclusions: AIS is associated with adverse distributions of LDL and HDL subclasses. In addition, short-term mortality after AIS is associated with increased sdLDL particles. Our results indicate that sdLDL is an independent predictor of both AIS onset and consecutive short-term mortality.
Keywords:
Cerebrovascular disease / Stroke / Outcome / Small, dense LDL / HDL subclassesSource:
Atherosclerosis, 2010, 210, 2, 548-554Publisher:
- Elsevier Ireland Ltd, Clare
Funding / projects:
DOI: 10.1016/j.atherosclerosis.2009.11.040
ISSN: 0021-9150
PubMed: 20022325
WoS: 000278036800038
Scopus: 2-s2.0-77953231797
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Institution/Community
PharmacyTY - JOUR AU - Zeljković, Aleksandra AU - Vekić, Jelena AU - Spasojević-Kalimanovska, Vesna AU - Jelić-Ivanović, Zorana AU - Bogavac-Stanojević, Nataša AU - Gulan, Brankica AU - Spasić, Slavica PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1415 AB - Objective: Small, dense low-density lipoprotein (sdLDL) and small-sized high-density lipoprotein (HDL) particles are established risk factors for ischemic heart disease. However, their clinical significance for acute ischemic stroke (AIS) is uncertain. This study evaluates associations of LDL and HDL particle sizes and subclasses with AIS risk and short-term mortality after AIS. Methods: Two hundred AIS patients hospitalised for first-in-a-lifetime stroke and 162 apparently healthy controls were included in the study. LDL and HDL particles were separated by gradient gel electrophoresis and serum lipid parameters were measured by standard laboratory methods. Baseline characteristics of LDL and HDL particles were evaluated for the prediction of AIS and short-term mortality after AIS. Results: AIS patients had significantly more LDL III and IVb, but less LDL I and II particles. They also had significantly smaller HDL size, more HDL 3a, 3b and 3c and less HDL 2b subclasses. The relative content of both sdLDL and small-sized HDL particles was significantly increased in patients (P lt 0.001 and P lt 0.001, respectively). In addition, sdLDL was significantly higher in AIS fatalities (n = 25) compared with survivors (n = 175, P lt 0.05). Increased sdLDL was a significant predictor of AIS (OR = 4.31; P lt 0.001) and in-hospital mortality after AIS (OR = 5.50; P lt 0.05). The observed relationships persisted after adjustment for conventional risk factors. Conclusions: AIS is associated with adverse distributions of LDL and HDL subclasses. In addition, short-term mortality after AIS is associated with increased sdLDL particles. Our results indicate that sdLDL is an independent predictor of both AIS onset and consecutive short-term mortality. PB - Elsevier Ireland Ltd, Clare T2 - Atherosclerosis T1 - LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality VL - 210 IS - 2 SP - 548 EP - 554 DO - 10.1016/j.atherosclerosis.2009.11.040 ER -
@article{ author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Bogavac-Stanojević, Nataša and Gulan, Brankica and Spasić, Slavica", year = "2010", abstract = "Objective: Small, dense low-density lipoprotein (sdLDL) and small-sized high-density lipoprotein (HDL) particles are established risk factors for ischemic heart disease. However, their clinical significance for acute ischemic stroke (AIS) is uncertain. This study evaluates associations of LDL and HDL particle sizes and subclasses with AIS risk and short-term mortality after AIS. Methods: Two hundred AIS patients hospitalised for first-in-a-lifetime stroke and 162 apparently healthy controls were included in the study. LDL and HDL particles were separated by gradient gel electrophoresis and serum lipid parameters were measured by standard laboratory methods. Baseline characteristics of LDL and HDL particles were evaluated for the prediction of AIS and short-term mortality after AIS. Results: AIS patients had significantly more LDL III and IVb, but less LDL I and II particles. They also had significantly smaller HDL size, more HDL 3a, 3b and 3c and less HDL 2b subclasses. The relative content of both sdLDL and small-sized HDL particles was significantly increased in patients (P lt 0.001 and P lt 0.001, respectively). In addition, sdLDL was significantly higher in AIS fatalities (n = 25) compared with survivors (n = 175, P lt 0.05). Increased sdLDL was a significant predictor of AIS (OR = 4.31; P lt 0.001) and in-hospital mortality after AIS (OR = 5.50; P lt 0.05). The observed relationships persisted after adjustment for conventional risk factors. Conclusions: AIS is associated with adverse distributions of LDL and HDL subclasses. In addition, short-term mortality after AIS is associated with increased sdLDL particles. Our results indicate that sdLDL is an independent predictor of both AIS onset and consecutive short-term mortality.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Atherosclerosis", title = "LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality", volume = "210", number = "2", pages = "548-554", doi = "10.1016/j.atherosclerosis.2009.11.040" }
Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Bogavac-Stanojević, N., Gulan, B.,& Spasić, S.. (2010). LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality. in Atherosclerosis Elsevier Ireland Ltd, Clare., 210(2), 548-554. https://doi.org/10.1016/j.atherosclerosis.2009.11.040
Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Bogavac-Stanojević N, Gulan B, Spasić S. LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality. in Atherosclerosis. 2010;210(2):548-554. doi:10.1016/j.atherosclerosis.2009.11.040 .
Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Bogavac-Stanojević, Nataša, Gulan, Brankica, Spasić, Slavica, "LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality" in Atherosclerosis, 210, no. 2 (2010):548-554, https://doi.org/10.1016/j.atherosclerosis.2009.11.040 . .