Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma concentrations of amitriptyline (AT), its active metabolite nortriptyline (NT) and clinical response. Fifteen patients with primary depression (according to DSM-IV) were divided in two groups according to given doses: (I) 6 patients received 3 x 50 mg of AT daily; and (II) 9 patients received 3 x 25 mg of AT daily, for 6 weeks. The clinical status was determined with Hamilton Depression Rating Scale. Both investigated doses were therapeutically effective. AT and NT plasma concentrations were assayed by high performance liquid chromatography. Following administration of 3 x 50 mg of AT daily, the correlation of concentrations of AT, NT, total AT+NT and clinical response were r(AT) = -0.702 (P lt 0.1), r(NT) = -0.761 (P lt 0.1), r(AT+NT) = -0.741 (P lt 0.1). The linear and very high correlation were also present with concentrations of AT, NT, total AT+NT and clinical respon...se in depressive patients on 3 x 25 mg AT daily: r(AT) = -0.785 (P lt 0.02), r(NT) = -0.811 (P lt 0.01), r(AT+NT) = -0.848 (P lt 0.01). Our results support a high correlation between AT/NT plasma concentrations and clinical response indicating that therapeutic monitoring of AT and its metabolite, NT, can provide eventual clinical response.
TY - JOUR
AU - Miljković, Branislava
AU - Pokrajac, Milena
AU - Timotijević, Ivana
AU - Varagić, V.M.
PY - 1996
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/142
AB - Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma concentrations of amitriptyline (AT), its active metabolite nortriptyline (NT) and clinical response. Fifteen patients with primary depression (according to DSM-IV) were divided in two groups according to given doses: (I) 6 patients received 3 x 50 mg of AT daily; and (II) 9 patients received 3 x 25 mg of AT daily, for 6 weeks. The clinical status was determined with Hamilton Depression Rating Scale. Both investigated doses were therapeutically effective. AT and NT plasma concentrations were assayed by high performance liquid chromatography. Following administration of 3 x 50 mg of AT daily, the correlation of concentrations of AT, NT, total AT+NT and clinical response were r(AT) = -0.702 (P lt 0.1), r(NT) = -0.761 (P lt 0.1), r(AT+NT) = -0.741 (P lt 0.1). The linear and very high correlation were also present with concentrations of AT, NT, total AT+NT and clinical response in depressive patients on 3 x 25 mg AT daily: r(AT) = -0.785 (P lt 0.02), r(NT) = -0.811 (P lt 0.01), r(AT+NT) = -0.848 (P lt 0.01). Our results support a high correlation between AT/NT plasma concentrations and clinical response indicating that therapeutic monitoring of AT and its metabolite, NT, can provide eventual clinical response.
PB - Medecine Et Hygiene, Geneva 4
T2 - European Journal of Drug Metabolism and Pharmacokinetics
T1 - Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients
VL - 21
IS - 3
SP - 251
EP - 255
DO - 10.1007/BF03189722
ER -
@article{
author = "Miljković, Branislava and Pokrajac, Milena and Timotijević, Ivana and Varagić, V.M.",
year = "1996",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/142",
abstract = "Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma concentrations of amitriptyline (AT), its active metabolite nortriptyline (NT) and clinical response. Fifteen patients with primary depression (according to DSM-IV) were divided in two groups according to given doses: (I) 6 patients received 3 x 50 mg of AT daily; and (II) 9 patients received 3 x 25 mg of AT daily, for 6 weeks. The clinical status was determined with Hamilton Depression Rating Scale. Both investigated doses were therapeutically effective. AT and NT plasma concentrations were assayed by high performance liquid chromatography. Following administration of 3 x 50 mg of AT daily, the correlation of concentrations of AT, NT, total AT+NT and clinical response were r(AT) = -0.702 (P lt 0.1), r(NT) = -0.761 (P lt 0.1), r(AT+NT) = -0.741 (P lt 0.1). The linear and very high correlation were also present with concentrations of AT, NT, total AT+NT and clinical response in depressive patients on 3 x 25 mg AT daily: r(AT) = -0.785 (P lt 0.02), r(NT) = -0.811 (P lt 0.01), r(AT+NT) = -0.848 (P lt 0.01). Our results support a high correlation between AT/NT plasma concentrations and clinical response indicating that therapeutic monitoring of AT and its metabolite, NT, can provide eventual clinical response.",
publisher = "Medecine Et Hygiene, Geneva 4",
journal = "European Journal of Drug Metabolism and Pharmacokinetics",
title = "Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients",
volume = "21",
number = "3",
pages = "251-255",
doi = "10.1007/BF03189722"
}
Miljković, B., Pokrajac, M., Timotijević, I.,& Varagić, V.M. (1996). Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients.
European Journal of Drug Metabolism and Pharmacokinetics
Medecine Et Hygiene, Geneva 4., 21(3), 251-255.
https://doi.org/10.1007/BF03189722
Miljković B, Pokrajac M, Timotijević I, Varagić V. Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients. European Journal of Drug Metabolism and Pharmacokinetics. 1996;21(3):251-255
Miljković Branislava, Pokrajac Milena, Timotijević Ivana, Varagić V.M., "Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients" European Journal of Drug Metabolism and Pharmacokinetics, 21, no. 3 (1996):251-255,
https://doi.org/10.1007/BF03189722 .
