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Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients

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1996
Authors
Miljković, Branislava
Pokrajac, Milena
Timotijević, Ivana
Varagić, V.M.
Article (Published version)
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Abstract
Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma concentrations of amitriptyline (AT), its active metabolite nortriptyline (NT) and clinical response. Fifteen patients with primary depression (according to DSM-IV) were divided in two groups according to given doses: (I) 6 patients received 3 x 50 mg of AT daily; and (II) 9 patients received 3 x 25 mg of AT daily, for 6 weeks. The clinical status was determined with Hamilton Depression Rating Scale. Both investigated doses were therapeutically effective. AT and NT plasma concentrations were assayed by high performance liquid chromatography. Following administration of 3 x 50 mg of AT daily, the correlation of concentrations of AT, NT, total AT+NT and clinical response were r(AT) = -0.702 (P lt 0.1), r(NT) = -0.761 (P lt 0.1), r(AT+NT) = -0.741 (P lt 0.1). The linear and very high correlation were also present with concentrations of AT, NT, total AT+NT and clinical respon...se in depressive patients on 3 x 25 mg AT daily: r(AT) = -0.785 (P lt 0.02), r(NT) = -0.811 (P lt 0.01), r(AT+NT) = -0.848 (P lt 0.01). Our results support a high correlation between AT/NT plasma concentrations and clinical response indicating that therapeutic monitoring of AT and its metabolite, NT, can provide eventual clinical response.

Keywords:
Amitriptyline / Clinical response / Correlation / Nortriptyline / Patients
Source:
European Journal of Drug Metabolism and Pharmacokinetics, 1996, 21, 3, 251-255
Publisher:
  • Medecine Et Hygiene, Geneva 4

DOI: 10.1007/BF03189722

ISSN: 0378-7966

PubMed: 8980924

WoS: A1996VZ02200009

Scopus: 2-s2.0-0030462288
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/142
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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