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dc.creatorPejović, Gordana
dc.creatorOtašević, Biljana
dc.creatorZečević, Mira
dc.creatorKuntić, Vesna
dc.creatorVujić, Zorica
dc.date.accessioned2019-09-02T11:22:29Z
dc.date.available2019-09-02T11:22:29Z
dc.date.issued2010
dc.identifier.issn1425-5073
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1432
dc.description.abstractThe present work describes forced degradation study of valdecoxib, under different ICH recommended stress conditions - photolytic degradation, oxidation, hydrolysis in alkaline and acidic conditions as well as its thermal degradation. Stress studies were performed at valdecoxib drug substance and the final dosage form. Chromatographic separations of drug and the degradation products formed under various experimental conditions was successfully achieved on RP-18e Chromolith® performance monolithic column (100 mm × 4.6 mm, macropore size 2 μm, mesopore size 13 nm) with an eluent containing the mixture of methanol and water solution of TEA (1%, pH 7.4) in the ratio 40:60 (v/v) while the column temperature was adjusted to 30°C. Detection was performed using photodiode array detector on several wavelengths in order to ensure the proper insight into drug degradation pathway in case the formed products differ in absorption characteristics.en
dc.rightsrestrictedAccess
dc.sourceFarmaceutyczny Przeglad Naukowy
dc.subjectForced degradation studiesen
dc.subjectStability-indicating methoden
dc.subjectValdecoxiben
dc.titleValdecoxib stability properties under forced degradation conditionsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВујић, Зорица; Кунтић, Весна; Зечевић, Мира; Пејовић, Гордана; Оташевић, Биљана;
dc.citation.volume7
dc.citation.issue9
dc.citation.spage11
dc.citation.epage17
dc.citation.other7(9): 11-17
dc.identifier.scopus2-s2.0-78650066523
dc.identifier.rcubconv_4983
dc.type.versionpublishedVersion


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