Two spectrophotometric methods are proposed for the determination of flurazepam in pharmaceutical formulations. The first one, a very sensitive and fast direct spectrophotometric method is based on the measurement of the absorbance of aqueous flurazepam monohydrochloride solution (pH 6) at the wavelength of maximum absorption at 230 nm. The second one, a difference spectrophotometric method, is based on the measurement of the absorbance difference between equimolar solutions of flurazepam monoprotonated (pH 6) and diprotonated (pH 0) forms at 225 nm. Both methods were applied to the determination of flurazepam in capsules which contain flurazepam monohydrochloride. To extend the application range of both methods, we examined optimum conditions which enable the determination of flurazepam in formulations in form of flurazepam dihydrochloride.
TY - JOUR
AU - Popović, Gordana
AU - Pfendt, Lidija
PY - 1996
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/144
AB - Two spectrophotometric methods are proposed for the determination of flurazepam in pharmaceutical formulations. The first one, a very sensitive and fast direct spectrophotometric method is based on the measurement of the absorbance of aqueous flurazepam monohydrochloride solution (pH 6) at the wavelength of maximum absorption at 230 nm. The second one, a difference spectrophotometric method, is based on the measurement of the absorbance difference between equimolar solutions of flurazepam monoprotonated (pH 6) and diprotonated (pH 0) forms at 225 nm. Both methods were applied to the determination of flurazepam in capsules which contain flurazepam monohydrochloride. To extend the application range of both methods, we examined optimum conditions which enable the determination of flurazepam in formulations in form of flurazepam dihydrochloride.
PB - Editions Scientifiques Elsevier, Paris Cedex 15
T2 - Analusis
T1 - Spectrophotometric determination of flurazepam in pharmaceutical formulations
VL - 24
IS - 6
SP - 259
EP - 262
UR - https://hdl.handle.net/21.15107/rcub_farfar_144
ER -
@article{
author = "Popović, Gordana and Pfendt, Lidija",
year = "1996",
abstract = "Two spectrophotometric methods are proposed for the determination of flurazepam in pharmaceutical formulations. The first one, a very sensitive and fast direct spectrophotometric method is based on the measurement of the absorbance of aqueous flurazepam monohydrochloride solution (pH 6) at the wavelength of maximum absorption at 230 nm. The second one, a difference spectrophotometric method, is based on the measurement of the absorbance difference between equimolar solutions of flurazepam monoprotonated (pH 6) and diprotonated (pH 0) forms at 225 nm. Both methods were applied to the determination of flurazepam in capsules which contain flurazepam monohydrochloride. To extend the application range of both methods, we examined optimum conditions which enable the determination of flurazepam in formulations in form of flurazepam dihydrochloride.",
publisher = "Editions Scientifiques Elsevier, Paris Cedex 15",
journal = "Analusis",
title = "Spectrophotometric determination of flurazepam in pharmaceutical formulations",
volume = "24",
number = "6",
pages = "259-262",
url = "https://hdl.handle.net/21.15107/rcub_farfar_144"
}
Popović, G.,& Pfendt, L.. (1996). Spectrophotometric determination of flurazepam in pharmaceutical formulations. in Analusis
Editions Scientifiques Elsevier, Paris Cedex 15., 24(6), 259-262.
https://hdl.handle.net/21.15107/rcub_farfar_144
Popović G, Pfendt L. Spectrophotometric determination of flurazepam in pharmaceutical formulations. in Analusis. 1996;24(6):259-262.
https://hdl.handle.net/21.15107/rcub_farfar_144 .
Popović, Gordana, Pfendt, Lidija, "Spectrophotometric determination of flurazepam in pharmaceutical formulations" in Analusis, 24, no. 6 (1996):259-262,
https://hdl.handle.net/21.15107/rcub_farfar_144 .
