Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients
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This report deals with the incidence and distribution of autoantibodies against well-defined human brain antigens S-100 and NSE in the development of neurologic and psychiatric syndromes. Serum samples from patients and controls were examined by means of an enzyme-linked immunosorbent assay (ELISA) for the presence of autoantibodies against human S-100 protein and NSE. The highest incidence of anti-S-100 and anti-NSE antibodies was in Parkinson's disease, Alzheimer's disease and senile dementia, and the lowest in schizophrenia and alcoholic syndrome. The frequency of anti-S-100 autoantibodies was higher than that of anti-NSE. In healthy individuals the incidence of antibrain antibodies was low. These results suggest the involvement of human autoimmune mechanism in the development of certain neuropsychiatric diseases.
Source:Jugoslovenska medicinska biohemija, 1997, 16, 4, 217-219
- Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd