This report deals with the incidence and distribution of autoantibodies against well-defined human brain antigens S-100 and NSE in the development of neurologic and psychiatric syndromes. Serum samples from patients and controls were examined by means of an enzyme-linked immunosorbent assay (ELISA) for the presence of autoantibodies against human S-100 protein and NSE. The highest incidence of anti-S-100 and anti-NSE antibodies was in Parkinson's disease, Alzheimer's disease and senile dementia, and the lowest in schizophrenia and alcoholic syndrome. The frequency of anti-S-100 autoantibodies was higher than that of anti-NSE. In healthy individuals the incidence of antibrain antibodies was low. These results suggest the involvement of human autoimmune mechanism in the development of certain neuropsychiatric diseases.
TY - JOUR
AU - Horvat, J
AU - Begović, D
AU - Stojić-Vukanić, Zorica
AU - Milošević, D
PY - 1997
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/145
AB - This report deals with the incidence and distribution of autoantibodies against well-defined human brain antigens S-100 and NSE in the development of neurologic and psychiatric syndromes. Serum samples from patients and controls were examined by means of an enzyme-linked immunosorbent assay (ELISA) for the presence of autoantibodies against human S-100 protein and NSE. The highest incidence of anti-S-100 and anti-NSE antibodies was in Parkinson's disease, Alzheimer's disease and senile dementia, and the lowest in schizophrenia and alcoholic syndrome. The frequency of anti-S-100 autoantibodies was higher than that of anti-NSE. In healthy individuals the incidence of antibrain antibodies was low. These results suggest the involvement of human autoimmune mechanism in the development of certain neuropsychiatric diseases.
PB - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2 - Jugoslovenska medicinska biohemija
T1 - Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients
VL - 16
IS - 4
SP - 217
EP - 219
ER -
@article{
author = "Horvat, J and Begović, D and Stojić-Vukanić, Zorica and Milošević, D",
year = "1997",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/145",
abstract = "This report deals with the incidence and distribution of autoantibodies against well-defined human brain antigens S-100 and NSE in the development of neurologic and psychiatric syndromes. Serum samples from patients and controls were examined by means of an enzyme-linked immunosorbent assay (ELISA) for the presence of autoantibodies against human S-100 protein and NSE. The highest incidence of anti-S-100 and anti-NSE antibodies was in Parkinson's disease, Alzheimer's disease and senile dementia, and the lowest in schizophrenia and alcoholic syndrome. The frequency of anti-S-100 autoantibodies was higher than that of anti-NSE. In healthy individuals the incidence of antibrain antibodies was low. These results suggest the involvement of human autoimmune mechanism in the development of certain neuropsychiatric diseases.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients",
volume = "16",
number = "4",
pages = "217-219"
}
Horvat, J., Begović, D., Stojić-Vukanić, Z.,& Milošević, D. (1997). Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients.
Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 16(4), 217-219.
Horvat J, Begović D, Stojić-Vukanić Z, Milošević D. Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients. Jugoslovenska medicinska biohemija. 1997;16(4):217-219
Horvat J, Begović D, Stojić-Vukanić Zorica, Milošević D, "Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients" Jugoslovenska medicinska biohemija, 16, no. 4 (1997):217-219
