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Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium

Thumbnail
2011
1449.pdf (147.8Kb)
Authors
Matović, Vesna
Buha, Aleksandra
Bulat, Zorica
Đukić-Ćosić, Danijela
Article (Published version)
Metadata
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Abstract
Discovered in late 1817, Cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to find out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically efficient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has beneficial effect under condition of cadmium. exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective... role of magnesium during cadmium exposure. These findings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.

Keywords:
carcinogenicity chelation therapy / dietary supplementation / essential elements
Source:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2011, 62, 1, 65-76
Publisher:
  • Inst Medical Research & Occupational Health, Zagreb
Funding / projects:
  • Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)

DOI: 10.2478/10004-1254-62-2011-2075

ISSN: 0004-1254

PubMed: 21421535

WoS: 000288884000009

Scopus: 2-s2.0-79953062331
[ Google Scholar ]
133
112
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1451
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Matović, Vesna
AU  - Buha, Aleksandra
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1451
AB  - Discovered in late 1817, Cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to find out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically efficient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has beneficial effect under condition of cadmium. exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These findings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.
PB  - Inst Medical Research & Occupational Health, Zagreb
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium
VL  - 62
IS  - 1
SP  - 65
EP  - 76
DO  - 10.2478/10004-1254-62-2011-2075
UR  - conv_2408
ER  - 
@article{
author = "Matović, Vesna and Buha, Aleksandra and Bulat, Zorica and Đukić-Ćosić, Danijela",
year = "2011",
abstract = "Discovered in late 1817, Cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to find out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically efficient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has beneficial effect under condition of cadmium. exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These findings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium",
volume = "62",
number = "1",
pages = "65-76",
doi = "10.2478/10004-1254-62-2011-2075",
url = "conv_2408"
}
Matović, V., Buha, A., Bulat, Z.,& Đukić-Ćosić, D.. (2011). Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 62(1), 65-76.
https://doi.org/10.2478/10004-1254-62-2011-2075
conv_2408
Matović V, Buha A, Bulat Z, Đukić-Ćosić D. Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2011;62(1):65-76.
doi:10.2478/10004-1254-62-2011-2075
conv_2408 .
Matović, Vesna, Buha, Aleksandra, Bulat, Zorica, Đukić-Ćosić, Danijela, "Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 62, no. 1 (2011):65-76,
https://doi.org/10.2478/10004-1254-62-2011-2075 .,
conv_2408 .

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