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Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system

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2011
Authors
Malenović, Anđelija
Dotsikas, Yannis
Masković, Marija
Jančić-Stojanović, Biljana
Ivanović, Darko
Medenica, Mirjana
Article (Published version)
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Abstract
In the current paper the application of multiobjective optimization (MOOP) technique, via Derringer's desirability function, to a microemulsion liquid chromatographic (MELC) method is described. Chromatographic separation of perindopril tert-butylamine and its four impurities was selected as the case study. Central composite design (CCD) with fractional factorial design, +/- 0.5 alpha star design and four replications in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. As factors that influence the system mostly (i) content of ethyl acetate and (ii) butyl acetate in composite internal phase, (iii) content of sodium dodecyl sulfate (surfactant) and (iv) n-butanol (co-surfactant). as well as (v) pH of the mobile phase were selected. Retention factor of (a) perindoprilat and (b) impurity Y 31 and
Keywords:
Derringer's desirability function / Microemulsion liquid chromatography / Multiobjective optimization / Perindopril impurities / Sensitivity analysis
Source:
Microchemical Journal, 2011, 99, 2, 454-460
Publisher:
  • Elsevier Science BV, Amsterdam
Projects:
  • Modelling of different chromatographic systems with chemometrical approach in pharmaceutical analysis (RS-172052)

DOI: 10.1016/j.microc.2011.06.022

ISSN: 0026-265X

WoS: 000295770700046

Scopus: 2-s2.0-80052375717
[ Google Scholar ]
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46
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1456
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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