In the current paper the application of multiobjective optimization (MOOP) technique, via Derringer's desirability function, to a microemulsion liquid chromatographic (MELC) method is described. Chromatographic separation of perindopril tert-butylamine and its four impurities was selected as the case study. Central composite design (CCD) with fractional factorial design, +/- 0.5 alpha star design and four replications in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. As factors that influence the system mostly (i) content of ethyl acetate and (ii) butyl acetate in composite internal phase, (iii) content of sodium dodecyl sulfate (surfactant) and (iv) n-butanol (co-surfactant). as well as (v) pH of the mobile phase were selected. Retention factor of (a) perindoprilat and (b) impurity Y 31 and
TY - JOUR
AU - Malenović, Anđelija
AU - Dotsikas, Yannis
AU - Masković, Marija
AU - Jančić-Stojanović, Biljana
AU - Ivanović, Darko
AU - Medenica, Mirjana
PY - 2011
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1456
AB - In the current paper the application of multiobjective optimization (MOOP) technique, via Derringer's desirability function, to a microemulsion liquid chromatographic (MELC) method is described. Chromatographic separation of perindopril tert-butylamine and its four impurities was selected as the case study. Central composite design (CCD) with fractional factorial design, +/- 0.5 alpha star design and four replications in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. As factors that influence the system mostly (i) content of ethyl acetate and (ii) butyl acetate in composite internal phase, (iii) content of sodium dodecyl sulfate (surfactant) and (iv) n-butanol (co-surfactant). as well as (v) pH of the mobile phase were selected. Retention factor of (a) perindoprilat and (b) impurity Y 31 and
PB - Elsevier Science BV, Amsterdam
T2 - Microchemical Journal
T1 - Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system
VL - 99
IS - 2
SP - 454
EP - 460
DO - 10.1016/j.microc.2011.06.022
ER -
@article{
author = "Malenović, Anđelija and Dotsikas, Yannis and Masković, Marija and Jančić-Stojanović, Biljana and Ivanović, Darko and Medenica, Mirjana",
year = "2011",
abstract = "In the current paper the application of multiobjective optimization (MOOP) technique, via Derringer's desirability function, to a microemulsion liquid chromatographic (MELC) method is described. Chromatographic separation of perindopril tert-butylamine and its four impurities was selected as the case study. Central composite design (CCD) with fractional factorial design, +/- 0.5 alpha star design and four replications in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. As factors that influence the system mostly (i) content of ethyl acetate and (ii) butyl acetate in composite internal phase, (iii) content of sodium dodecyl sulfate (surfactant) and (iv) n-butanol (co-surfactant). as well as (v) pH of the mobile phase were selected. Retention factor of (a) perindoprilat and (b) impurity Y 31 and",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Microchemical Journal",
title = "Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system",
volume = "99",
number = "2",
pages = "454-460",
doi = "10.1016/j.microc.2011.06.022"
}
Malenović, A., Dotsikas, Y., Masković, M., Jančić-Stojanović, B., Ivanović, D.,& Medenica, M.. (2011). Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system. in Microchemical Journal
Elsevier Science BV, Amsterdam., 99(2), 454-460.
https://doi.org/10.1016/j.microc.2011.06.022
Malenović A, Dotsikas Y, Masković M, Jančić-Stojanović B, Ivanović D, Medenica M. Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system. in Microchemical Journal. 2011;99(2):454-460.
doi:10.1016/j.microc.2011.06.022 .
Malenović, Anđelija, Dotsikas, Yannis, Masković, Marija, Jančić-Stojanović, Biljana, Ivanović, Darko, Medenica, Mirjana, "Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system" in Microchemical Journal, 99, no. 2 (2011):454-460,
https://doi.org/10.1016/j.microc.2011.06.022 . .
