Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system
Authorized Users Only
2011
Authors
Malenović, Anđelija
Dotsikas, Yannis

Masković, Marija
Jančić-Stojanović, Biljana

Ivanović, Darko
Medenica, Mirjana
Article (Published version)

Metadata
Show full item recordAbstract
In the current paper the application of multiobjective optimization (MOOP) technique, via Derringer's desirability function, to a microemulsion liquid chromatographic (MELC) method is described. Chromatographic separation of perindopril tert-butylamine and its four impurities was selected as the case study. Central composite design (CCD) with fractional factorial design, +/- 0.5 alpha star design and four replications in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. As factors that influence the system mostly (i) content of ethyl acetate and (ii) butyl acetate in composite internal phase, (iii) content of sodium dodecyl sulfate (surfactant) and (iv) n-butanol (co-surfactant). as well as (v) pH of the mobile phase were selected. Retention factor of (a) perindoprilat and (b) impurity Y 31 and
Keywords:
Derringer's desirability function / Microemulsion liquid chromatography / Multiobjective optimization / Perindopril impurities / Sensitivity analysisSource:
Microchemical Journal, 2011, 99, 2, 454-460Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
- Modelling of different chromatographic systems with chemometrical approach in pharmaceutical analysis (RS-172052)
DOI: 10.1016/j.microc.2011.06.022
ISSN: 0026-265X
WoS: 000295770700046
Scopus: 2-s2.0-80052375717
Collections
Institution/Community
PharmacyTY - JOUR AU - Malenović, Anđelija AU - Dotsikas, Yannis AU - Masković, Marija AU - Jančić-Stojanović, Biljana AU - Ivanović, Darko AU - Medenica, Mirjana PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1456 AB - In the current paper the application of multiobjective optimization (MOOP) technique, via Derringer's desirability function, to a microemulsion liquid chromatographic (MELC) method is described. Chromatographic separation of perindopril tert-butylamine and its four impurities was selected as the case study. Central composite design (CCD) with fractional factorial design, +/- 0.5 alpha star design and four replications in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. As factors that influence the system mostly (i) content of ethyl acetate and (ii) butyl acetate in composite internal phase, (iii) content of sodium dodecyl sulfate (surfactant) and (iv) n-butanol (co-surfactant). as well as (v) pH of the mobile phase were selected. Retention factor of (a) perindoprilat and (b) impurity Y 31 and PB - Elsevier Science BV, Amsterdam T2 - Microchemical Journal T1 - Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system VL - 99 IS - 2 SP - 454 EP - 460 DO - 10.1016/j.microc.2011.06.022 ER -
@article{ author = "Malenović, Anđelija and Dotsikas, Yannis and Masković, Marija and Jančić-Stojanović, Biljana and Ivanović, Darko and Medenica, Mirjana", year = "2011", abstract = "In the current paper the application of multiobjective optimization (MOOP) technique, via Derringer's desirability function, to a microemulsion liquid chromatographic (MELC) method is described. Chromatographic separation of perindopril tert-butylamine and its four impurities was selected as the case study. Central composite design (CCD) with fractional factorial design, +/- 0.5 alpha star design and four replications in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. As factors that influence the system mostly (i) content of ethyl acetate and (ii) butyl acetate in composite internal phase, (iii) content of sodium dodecyl sulfate (surfactant) and (iv) n-butanol (co-surfactant). as well as (v) pH of the mobile phase were selected. Retention factor of (a) perindoprilat and (b) impurity Y 31 and", publisher = "Elsevier Science BV, Amsterdam", journal = "Microchemical Journal", title = "Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system", volume = "99", number = "2", pages = "454-460", doi = "10.1016/j.microc.2011.06.022" }
Malenović, A., Dotsikas, Y., Masković, M., Jančić-Stojanović, B., Ivanović, D.,& Medenica, M.. (2011). Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system. in Microchemical Journal Elsevier Science BV, Amsterdam., 99(2), 454-460. https://doi.org/10.1016/j.microc.2011.06.022
Malenović A, Dotsikas Y, Masković M, Jančić-Stojanović B, Ivanović D, Medenica M. Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system. in Microchemical Journal. 2011;99(2):454-460. doi:10.1016/j.microc.2011.06.022 .
Malenović, Anđelija, Dotsikas, Yannis, Masković, Marija, Jančić-Stojanović, Biljana, Ivanović, Darko, Medenica, Mirjana, "Desirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC system" in Microchemical Journal, 99, no. 2 (2011):454-460, https://doi.org/10.1016/j.microc.2011.06.022 . .