Приказ основних података о документу

dc.creatorMalenović, Anđelija
dc.creatorDotsikas, Yannis
dc.creatorMasković, Marija
dc.creatorJančić-Stojanović, Biljana
dc.creatorIvanović, Darko
dc.creatorMedenica, Mirjana
dc.date.accessioned2019-09-02T11:23:02Z
dc.date.available2019-09-02T11:23:02Z
dc.date.issued2011
dc.identifier.issn0026-265X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1456
dc.description.abstractIn the current paper the application of multiobjective optimization (MOOP) technique, via Derringer's desirability function, to a microemulsion liquid chromatographic (MELC) method is described. Chromatographic separation of perindopril tert-butylamine and its four impurities was selected as the case study. Central composite design (CCD) with fractional factorial design, +/- 0.5 alpha star design and four replications in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. As factors that influence the system mostly (i) content of ethyl acetate and (ii) butyl acetate in composite internal phase, (iii) content of sodium dodecyl sulfate (surfactant) and (iv) n-butanol (co-surfactant). as well as (v) pH of the mobile phase were selected. Retention factor of (a) perindoprilat and (b) impurity Y 31 anden
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.rightsrestrictedAccess
dc.sourceMicrochemical Journal
dc.subjectDerringer's desirability functionen
dc.subjectMicroemulsion liquid chromatographyen
dc.subjectMultiobjective optimizationen
dc.subjectPerindopril impuritiesen
dc.subjectSensitivity analysisen
dc.titleDesirability-based optimization and its sensitivity analysis for the perindopril and its impurities analysis in a microemulsion LC systemen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДотсикас, Yаннис; Јанчић-Стојановић, Биљана; Меденица, Мирјана; Маленовић, Aнђелија; Ивановић, Дарко; Масковић, Марија;
dc.citation.volume99
dc.citation.issue2
dc.citation.spage454
dc.citation.epage460
dc.citation.other99(2): 454-460
dc.citation.rankM21
dc.identifier.wos000295770700046
dc.identifier.doi10.1016/j.microc.2011.06.022
dc.identifier.scopus2-s2.0-80052375717
dc.type.versionpublishedVersion


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Приказ основних података о документу