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dc.creatorJančić-Stojanović, Biljana
dc.creatorRakić, Tijana
dc.creatorKostić, Nada
dc.creatorVemić, Ana
dc.creatorMalenović, Anđelija
dc.creatorIvanović, D.
dc.creatorMedenica, Mirjana
dc.date.accessioned2019-09-02T11:23:30Z
dc.date.available2019-09-02T11:23:30Z
dc.date.issued2011
dc.identifier.issn0039-9140
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1477
dc.description.abstractIn this paper a new chromatographic response function (CRF) is designed and proposed for utilization in the optimization strategies. The function capability to represent the overall quality of a experimentally obtained chromatograms was compared to the other two objective functions and proved to give more accurate and reliable results. The new CRF has improved concept of separation and time term estimation. It reflects all important defects of the chromatogram such as the appearance of asymmetrical or overlapping peaks and prolonged elution time and allows the appropriate weighting of each of them. The LC separation of raloxifene and its four impurities was evaluated through the central composite design experimental plan choosing the new CRF to be the only output of the system. The function demonstrated the ability to judge the impact of the complex interactions of the selected chromatographic parameters (acetonitrile content in the mobile phase, sodium dodecyl sulfate concentration in the water phase, pH of the mobile phase and column temperature) on the mixture behavior and led to the determination of the optimal separation conditions. The newly developed CRF proved to have the advanced performances and it presents the important step forward in the optimization of the chromatographic separation.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.rightsrestrictedAccess
dc.sourceTalanta
dc.subjectChromatographic response function (CRF)en
dc.subjectOptimizationen
dc.subjectRaloxifeneen
dc.subjectImpuritiesen
dc.subjectLiquid chromatographyen
dc.titleAdvancement in optimization tactic achieved by newly developed chromatographic response function: Application to LC separation of raloxifene and its impuritiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМеденица, Мирјана; Костић, Нада; Јанчић-Стојановић, Биљана; Вемић, Aна; Ракић, Тијана; Маленовић, Aнђелија; Ивановић, Д.;
dc.citation.volume85
dc.citation.issue3
dc.citation.spage1453
dc.citation.epage1460
dc.citation.other85(3): 1453-1460
dc.citation.rankM21
dc.identifier.wos000294092800036
dc.identifier.doi10.1016/j.talanta.2011.06.029
dc.identifier.pmid21807209
dc.identifier.scopus2-s2.0-79961126546
dc.identifier.rcubconv_2499
dc.type.versionpublishedVersion


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