Influence of sodium chloride on the release of diclofenac sodium from enteric-coated tablets
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The influence of sodium chloride addition on the drug release from enteric-coated tablets was assessed with a USP rotating-basket dissolution apparatus. Three brands of commercially available diclofenac sodium enteric-coated tablets were evaluated. Dissolution study was performed in the dissolution medium prepared with and without addition of sodium chloride. In order to test the difference between dissolution profiles obtained, statistical moment analysis and analysis of variance were performed.
Source:Pharmaceutical and Pharmacological Letters, 1997, 7, 4, 181-183
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