Immunoreactive neuropeptides in the cells of human thymus
Abstract
The study was designed to explore the expression of different neuropeptides, viz. vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP), bombesin and motilin in the cells of fetal and adult human thymus. Immunohistochemical staining revealed that cortical and medullary thymocytes were labeled by all antibodies, except those specific for motilin. Immunoreactive VIP and SP were observed in the solitary epithelial cells located in the subcapsular/subtrabecular cortex, at the corticomedullary junction and in the medulla. The cells within the subcapsular/subtrabecular monolayer, rare solitary cells in the deep cortex and epithelial cell network in the medulla, were labeled with antibodies to CGRP and bombesin. Hassall's corpuscles were labeled with all antibodies except that specific for SP. The obtained data obtained testify to the expression of different neuropeptides in human thymic lymphoid and non-lymphoid cells and suggest a role for neuroendocr...ine hormone-mediated mechanisms in the regulation of thymic homeostasis in humans.
Keywords:
VIP / Substance P / CGRP / bombesin / motilin / human thymusSource:
Archives of Biological Sciences, 2011, 63, 4, 971-977Publisher:
- Srpsko biološko društvo, Beograd, i dr.
Funding / projects:
DOI: 10.2298/ABS1104971L
ISSN: 0354-4664
WoS: 000299244500008
Scopus: 2-s2.0-84857986780
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Institution/Community
PharmacyTY - JOUR AU - Leposavić, Gordana AU - Todorović, Vera AU - Nikolić, I. AU - Perišić, Milica PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1491 AB - The study was designed to explore the expression of different neuropeptides, viz. vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP), bombesin and motilin in the cells of fetal and adult human thymus. Immunohistochemical staining revealed that cortical and medullary thymocytes were labeled by all antibodies, except those specific for motilin. Immunoreactive VIP and SP were observed in the solitary epithelial cells located in the subcapsular/subtrabecular cortex, at the corticomedullary junction and in the medulla. The cells within the subcapsular/subtrabecular monolayer, rare solitary cells in the deep cortex and epithelial cell network in the medulla, were labeled with antibodies to CGRP and bombesin. Hassall's corpuscles were labeled with all antibodies except that specific for SP. The obtained data obtained testify to the expression of different neuropeptides in human thymic lymphoid and non-lymphoid cells and suggest a role for neuroendocrine hormone-mediated mechanisms in the regulation of thymic homeostasis in humans. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Immunoreactive neuropeptides in the cells of human thymus VL - 63 IS - 4 SP - 971 EP - 977 DO - 10.2298/ABS1104971L ER -
@article{ author = "Leposavić, Gordana and Todorović, Vera and Nikolić, I. and Perišić, Milica", year = "2011", abstract = "The study was designed to explore the expression of different neuropeptides, viz. vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP), bombesin and motilin in the cells of fetal and adult human thymus. Immunohistochemical staining revealed that cortical and medullary thymocytes were labeled by all antibodies, except those specific for motilin. Immunoreactive VIP and SP were observed in the solitary epithelial cells located in the subcapsular/subtrabecular cortex, at the corticomedullary junction and in the medulla. The cells within the subcapsular/subtrabecular monolayer, rare solitary cells in the deep cortex and epithelial cell network in the medulla, were labeled with antibodies to CGRP and bombesin. Hassall's corpuscles were labeled with all antibodies except that specific for SP. The obtained data obtained testify to the expression of different neuropeptides in human thymic lymphoid and non-lymphoid cells and suggest a role for neuroendocrine hormone-mediated mechanisms in the regulation of thymic homeostasis in humans.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Immunoreactive neuropeptides in the cells of human thymus", volume = "63", number = "4", pages = "971-977", doi = "10.2298/ABS1104971L" }
Leposavić, G., Todorović, V., Nikolić, I.,& Perišić, M.. (2011). Immunoreactive neuropeptides in the cells of human thymus. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 63(4), 971-977. https://doi.org/10.2298/ABS1104971L
Leposavić G, Todorović V, Nikolić I, Perišić M. Immunoreactive neuropeptides in the cells of human thymus. in Archives of Biological Sciences. 2011;63(4):971-977. doi:10.2298/ABS1104971L .
Leposavić, Gordana, Todorović, Vera, Nikolić, I., Perišić, Milica, "Immunoreactive neuropeptides in the cells of human thymus" in Archives of Biological Sciences, 63, no. 4 (2011):971-977, https://doi.org/10.2298/ABS1104971L . .