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Immunoreactive neuropeptides in the cells of human thymus

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2011
1489.pdf (634.1Kb)
Authors
Leposavić, Gordana
Todorović, Vera
Nikolić, I.
Perišić, Milica
Article (Published version)
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Abstract
The study was designed to explore the expression of different neuropeptides, viz. vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP), bombesin and motilin in the cells of fetal and adult human thymus. Immunohistochemical staining revealed that cortical and medullary thymocytes were labeled by all antibodies, except those specific for motilin. Immunoreactive VIP and SP were observed in the solitary epithelial cells located in the subcapsular/subtrabecular cortex, at the corticomedullary junction and in the medulla. The cells within the subcapsular/subtrabecular monolayer, rare solitary cells in the deep cortex and epithelial cell network in the medulla, were labeled with antibodies to CGRP and bombesin. Hassall's corpuscles were labeled with all antibodies except that specific for SP. The obtained data obtained testify to the expression of different neuropeptides in human thymic lymphoid and non-lymphoid cells and suggest a role for neuroendocr...ine hormone-mediated mechanisms in the regulation of thymic homeostasis in humans.

Keywords:
VIP / Substance P / CGRP / bombesin / motilin / human thymus
Source:
Archives of Biological Sciences, 2011, 63, 4, 971-977
Publisher:
  • Srpsko biološko društvo, Beograd, i dr.
Funding / projects:
  • Immune system plasticity during aging: Immunomodulatory capacity of oestrogens (RS-175050)

DOI: 10.2298/ABS1104971L

ISSN: 0354-4664

WoS: 000299244500008

Scopus: 2-s2.0-84857986780
[ Google Scholar ]
1
1
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1491
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Leposavić, Gordana
AU  - Todorović, Vera
AU  - Nikolić, I.
AU  - Perišić, Milica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1491
AB  - The study was designed to explore the expression of different neuropeptides, viz. vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP), bombesin and motilin in the cells of fetal and adult human thymus. Immunohistochemical staining revealed that cortical and medullary thymocytes were labeled by all antibodies, except those specific for motilin. Immunoreactive VIP and SP were observed in the solitary epithelial cells located in the subcapsular/subtrabecular cortex, at the corticomedullary junction and in the medulla. The cells within the subcapsular/subtrabecular monolayer, rare solitary cells in the deep cortex and epithelial cell network in the medulla, were labeled with antibodies to CGRP and bombesin. Hassall's corpuscles were labeled with all antibodies except that specific for SP. The obtained data obtained testify to the expression of different neuropeptides in human thymic lymphoid and non-lymphoid cells and suggest a role for neuroendocrine hormone-mediated mechanisms in the regulation of thymic homeostasis in humans.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Immunoreactive neuropeptides in the cells of human thymus
VL  - 63
IS  - 4
SP  - 971
EP  - 977
DO  - 10.2298/ABS1104971L
UR  - conv_2574
ER  - 
@article{
author = "Leposavić, Gordana and Todorović, Vera and Nikolić, I. and Perišić, Milica",
year = "2011",
abstract = "The study was designed to explore the expression of different neuropeptides, viz. vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP), bombesin and motilin in the cells of fetal and adult human thymus. Immunohistochemical staining revealed that cortical and medullary thymocytes were labeled by all antibodies, except those specific for motilin. Immunoreactive VIP and SP were observed in the solitary epithelial cells located in the subcapsular/subtrabecular cortex, at the corticomedullary junction and in the medulla. The cells within the subcapsular/subtrabecular monolayer, rare solitary cells in the deep cortex and epithelial cell network in the medulla, were labeled with antibodies to CGRP and bombesin. Hassall's corpuscles were labeled with all antibodies except that specific for SP. The obtained data obtained testify to the expression of different neuropeptides in human thymic lymphoid and non-lymphoid cells and suggest a role for neuroendocrine hormone-mediated mechanisms in the regulation of thymic homeostasis in humans.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Immunoreactive neuropeptides in the cells of human thymus",
volume = "63",
number = "4",
pages = "971-977",
doi = "10.2298/ABS1104971L",
url = "conv_2574"
}
Leposavić, G., Todorović, V., Nikolić, I.,& Perišić, M.. (2011). Immunoreactive neuropeptides in the cells of human thymus. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 63(4), 971-977.
https://doi.org/10.2298/ABS1104971L
conv_2574
Leposavić G, Todorović V, Nikolić I, Perišić M. Immunoreactive neuropeptides in the cells of human thymus. in Archives of Biological Sciences. 2011;63(4):971-977.
doi:10.2298/ABS1104971L
conv_2574 .
Leposavić, Gordana, Todorović, Vera, Nikolić, I., Perišić, Milica, "Immunoreactive neuropeptides in the cells of human thymus" in Archives of Biological Sciences, 63, no. 4 (2011):971-977,
https://doi.org/10.2298/ABS1104971L .,
conv_2574 .

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