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dc.creatorSavić, Ivan
dc.creatorMarinković, Valentina
dc.creatorSavić, Ivana
dc.creatorSibinović, Predrag
dc.date.accessioned2019-09-02T11:24:01Z
dc.date.available2019-09-02T11:24:01Z
dc.date.issued2011
dc.identifier.issn0019-5464
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1498
dc.description.abstractThe aim of this work was to select an appropriate primary packaging and analysis of its influence on stability, of tablets containing Carvedilol (Karvileks, Zdravlje-Actavis, Serbia). The influence of different primary packaging materials and doses radiation was investigated. Karvileks tablets were put in an opaque plastic container, red and white blister packs, composed of polyvinyl chloride and aluminum foil (PVC/Al). After radiation, the content was estimated using a validated HPLC method. Tablets, packaged in different primary packaging materials, were exposed at different doses of UV and VIS radiation. In case of blister packs, the content of active substance was lower than 85% compared with an initial content. Tablets packaged in the opaque plastic containers, the content of carvedilol was not lower than 90%, after radiation. The study showed that the opaque plastic containers provide better photo protection than red and white blister packs for solid oral dosage forms of Karvileks.en
dc.publisherAssoc Pharmaceutical Teachers India, Bangalore
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34012/RS//
dc.rightsrestrictedAccess
dc.sourceIndian Journal of Pharmaceutical Education and Research
dc.subjectKarvileksen
dc.subjectphotostabilityen
dc.subjectHPLCen
dc.subjectpackagingen
dc.subjecttabletsen
dc.titleStudy of the Influence of Primary Packaging on Photostability of Tablets Containing Carvedilolen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСибиновић, Предраг; Савић, Ивана; Савић, Иван; Маринковић, Валентина;
dc.citation.volume45
dc.citation.issue4
dc.citation.spage353
dc.citation.epage359
dc.citation.other45(4): 353-359
dc.citation.rankM23
dc.identifier.wos000300830800011
dc.identifier.scopus2-s2.0-83055193645
dc.identifier.rcubconv_2598
dc.type.versionpublishedVersion


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