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dc.creatorDajak, Marijana
dc.creatorIgnjatović, Svetlana
dc.creatorStojimirović, Biljana
dc.creatorGajić, Snežana
dc.creatorMajkić-Singh, Nada
dc.date.accessioned2019-09-02T11:24:01Z
dc.date.available2019-09-02T11:24:01Z
dc.date.issued2011
dc.identifier.issn1433-6510
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1499
dc.description.abstractBackground: Beta-trace protein (BTP) was found to be increased in the serum and urine of patients with renal diseases. The aim of this study was to compare the urinary levels of beta-trace protein with levels of other urinary proteins: albumin, beta(2)-microglobulin (B2M), alpha(1)-microglobulin (A1M), and cystatin C and to determine its clinical usefulness for detection of renal dysfunction in chronic kidney disease (CKD). Methods: These markers were measured in 24-hour urine samples from 134 patients with CKD. Results: BTP correlated significantly with A1M (r = 0.871), cystatin C (r = 0.759), total protein (r = 0.684), B2M (r = 0.497), and albumin (r = 0.448) in 24-hour urine samples (P lt 0.05). Urinary BTP concentrations in patients with albuminuria below 30 mg / day were significantly lower than in patients with albuminuria above 30 mg / day (P lt 0.0001). ROC analysis showed high diagnostic accuracy of BTP for detection of > 30 mg / day albuminuria (AUC 0.908). Urinary BTP was also in significant correlation with the estimated glomerular filtration rate (r = -0.580). Conclusions: The results of our study suggest that BTP may be a useful and reliable urinary marker of renal dysfunction and may have a place in addition to urinary alpha(1)-microglobulin and albumin as an alternative marker for tubular damage and the magnitude of renal impairment in patients with chronic kidney disease. (Clin. Lab. 2011;57:29-36)en
dc.publisherClin Lab Publ, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Laboratory
dc.subjectChronic kidney diseaseen
dc.subjecturinary beta-trace proteinen
dc.subjecturinary proteinsen
dc.titleEvaluation of Renal Damage by Urinary Beta-Trace Protein in Patients with Chronic Kidney Diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМајкић-Сингх, Нада; Игњатовић, Светлана; Дајак, Маријана; Стојимировић, Биљана; Гајић, Снежана;
dc.citation.volume57
dc.citation.issue1-2
dc.citation.spage29
dc.citation.epage36
dc.citation.other57(1-2): 29-36
dc.citation.rankM23
dc.identifier.wos000288642000004
dc.identifier.pmid21391462
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_farfar_1499
dc.type.versionpublishedVersion


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