Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone
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2011
Authors
Marković, Violeta
Erić, Slavica

Juranić, Zorica
Stanojković, Tatjana

Joksović, Ljubinka
Ranković, Branislav
Kosanić, Marijana

Joksović, Milan D.
Article (Published version)

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A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.
Keywords:
Edaravone derivatives / Antitumor activity / QSAR studiesSource:
Bioorganic Chemistry, 2011, 39, 1-3, 18-27Publisher:
- Academic Press Inc Elsevier Science, San Diego
Funding / projects:
DOI: 10.1016/j.bioorg.2010.10.003
ISSN: 0045-2068
PubMed: 21078519
WoS: 000307423100003
Scopus: 2-s2.0-78751647459
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PharmacyTY - JOUR AU - Marković, Violeta AU - Erić, Slavica AU - Juranić, Zorica AU - Stanojković, Tatjana AU - Joksović, Ljubinka AU - Ranković, Branislav AU - Kosanić, Marijana AU - Joksović, Milan D. PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1500 AB - A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors. PB - Academic Press Inc Elsevier Science, San Diego T2 - Bioorganic Chemistry T1 - Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone VL - 39 IS - 1-3 SP - 18 EP - 27 DO - 10.1016/j.bioorg.2010.10.003 ER -
@article{ author = "Marković, Violeta and Erić, Slavica and Juranić, Zorica and Stanojković, Tatjana and Joksović, Ljubinka and Ranković, Branislav and Kosanić, Marijana and Joksović, Milan D.", year = "2011", abstract = "A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.", publisher = "Academic Press Inc Elsevier Science, San Diego", journal = "Bioorganic Chemistry", title = "Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone", volume = "39", number = "1-3", pages = "18-27", doi = "10.1016/j.bioorg.2010.10.003" }
Marković, V., Erić, S., Juranić, Z., Stanojković, T., Joksović, L., Ranković, B., Kosanić, M.,& Joksović, M. D.. (2011). Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone. in Bioorganic Chemistry Academic Press Inc Elsevier Science, San Diego., 39(1-3), 18-27. https://doi.org/10.1016/j.bioorg.2010.10.003
Marković V, Erić S, Juranić Z, Stanojković T, Joksović L, Ranković B, Kosanić M, Joksović MD. Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone. in Bioorganic Chemistry. 2011;39(1-3):18-27. doi:10.1016/j.bioorg.2010.10.003 .
Marković, Violeta, Erić, Slavica, Juranić, Zorica, Stanojković, Tatjana, Joksović, Ljubinka, Ranković, Branislav, Kosanić, Marijana, Joksović, Milan D., "Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone" in Bioorganic Chemistry, 39, no. 1-3 (2011):18-27, https://doi.org/10.1016/j.bioorg.2010.10.003 . .