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Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone

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2011
Authors
Marković, Violeta
Erić, Slavica
Juranić, Zorica
Stanojković, Tatjana
Joksović, Ljubinka
Ranković, Branislav
Kosanić, Marijana
Joksović, Milan D.
Article (Published version)
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Abstract
A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.
Keywords:
Edaravone derivatives / Antitumor activity / QSAR studies
Source:
Bioorganic Chemistry, 2011, 39, 1-3, 18-27
Publisher:
  • Academic Press Inc Elsevier Science, San Diego
Projects:
  • Synthesis, modeling, physicochemical and biological properties of organic compounds and related metal complexes (RS-172016)

DOI: 10.1016/j.bioorg.2010.10.003

ISSN: 0045-2068

PubMed: 21078519

WoS: 000307423100003

Scopus: 2-s2.0-78751647459
[ Google Scholar ]
17
17
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1500
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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