Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone
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2011
Authors
Marković, Violeta
Erić, Slavica
Juranić, Zorica
Stanojković, Tatjana

Joksović, Ljubinka
Ranković, Branislav
Kosanić, Marijana

Joksović, Milan D.
Article (Published version)

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Show full item recordAbstract
A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.
Keywords:
Edaravone derivatives / Antitumor activity / QSAR studiesSource:
Bioorganic Chemistry, 2011, 39, 1-3, 18-27Publisher:
- Academic Press Inc Elsevier Science, San Diego
Projects:
DOI: 10.1016/j.bioorg.2010.10.003
ISSN: 0045-2068
PubMed: 21078519